Song selectivity in the pallial-basal ganglia song circuit of zebra finches raised without tutor song exposure
Song selectivity in the pallial-basal ganglia song circuit of zebra finches raised without tutor song exposure
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DOI：
10.1152/jn.00916.2006
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发表时间：
2007-10-01
影响因子：
2.5
通讯作者：
Doupe, Allison J.
中科院分区：
文献类型：
--
作者：
Kojima, Satoshi;Doupe, Allison J.
声学体验严重影响听觉皮层的发育以及鸣禽感觉运动回路中高度选择性听觉神经元的出现。在成年斑胸草雀中，这些“歌曲选择性”神经元对鸟类自己的歌曲（BOS）的反应比对其他同种鸟类的歌曲的反应更好。鸟类通过记住导师的歌曲，然后将声音的听觉反馈与导师的歌曲记忆相匹配来学习歌曲。称为前前脑通路 (AFP) 的大脑皮层基底神经节回路中的歌曲选择性神经元反映了 BOS 的发育。然而，在学习过程中，它们也会对导师歌曲做出强烈反应，并且当鸟类无法将 BOS 与导师匹配时，它们的成年选择性就会受到损害，这表明选择性取决于导师歌曲学习以及 BOS 反馈与导师歌曲记忆的感觉运动匹配。我们通过记录未与成年同种动物饲养的鸟类的 AFP 神经元记录，研究了导师鸣叫的感觉学习对鸣叫选择性的贡献。我们发现这些“孤立”鸟类的 AFP 神经元对分离 BOS 具有高度协调的反应。由于对同种鸣叫的反应异常弱，其选择性同样高，并且在纹状体-苍白球核 X 区，甚至高于正常鸟类。这些结果表明，导师歌曲的感觉学习对于 AFP 神经元的 BOS 调整来说不是必需的。由于孤立的鸟类通过感觉运动学习来发展它们的鸣叫，因此我们的数据进一步说明了个体感觉运动学习对于鸣叫选择性的重要性，并提供了对鸣叫选择性神经元可能功能的深入了解。
Acoustic experience critically influences auditory cortical development as well as emergence of highly selective auditory neurons in the songbird sensorimotor circuit. In adult zebra finches, these "song-selective" neurons respond better to the bird's own song (BOS) than to songs of other conspecifics. Birds learn their songs by memorizing a tutor's song and then matching auditory feedback of their voice to the tutor song memory. Song-selective neurons in the pallial-basal ganglia circuit called the anterior forebrain pathway (AFP) reflect the development of BOS. However, during learning, they also respond strongly to tutor song and are compromised in their adult selectivity when birds are prevented from matching BOS to tutor, suggesting that selectivity depends on tutor song learning as well as sensorimotor matching of BOS feedback to the tutor song memory. We examined the contribution of sensory learning of tutor song to song selectivity by recording from AFP neurons in birds reared without exposure to adult conspecifics. We found that AFP neurons in these "isolate" birds had highly tuned responses to isolate BOS. The selectivity was as high, and in the striato-pallidal nucleus Area X, even higher than that in normal birds, due to abnormally weak responsiveness to conspecific song. These results demonstrate that sensory learning of tutor song is not necessary for BOS tuning of AFP neurons. Because isolate birds develop their song via sensorimotor learning, our data further illustrate the importance of individual sensorimotor learning for song selectivity and provide insight into possible functions of song-selective neurons.