Mast cells and IgE: from history to today.
Mast cells and IgE: from history to today.
复制标题
肥大细胞和 IgE：从历史到今天。
DOI：
10.2332/allergolint.13-rai-0537
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
K. Ishizaka
中科院分区：
文献类型：
--
作者：
H. Saito;T. Ishizaka;K. Ishizaka
在1966年发现IgE之前，肥大细胞在变态反应中的作用一直没有确定。然后，从一名致命性骨髓瘤患者捐赠的许多升血浆中提纯的IgE被分发给世界各地的研究人员，从而加速了对过敏反应机制的探索，特别是肥大细胞和嗜碱性粒细胞在IgE介导的反应中的作用。1977年，肥大细胞被鉴定为骨髓造血干细胞的后代，这使我们成功地进行了人类肥大细胞的体外培养。随着分子生物学技术的发展，高亲和力Ig E受体(FcεRI)的结构于1989年被确定。这些发现和随后的研究加深了对过去半个世纪中IgE介导的过敏性疾病的理解，特别是肥大细胞参与的过敏性疾病。我们现在甚至已经获得了FcεRI依赖激活的肥大细胞的全基因组表达的信息。与我们对涉及IgE和肥大细胞的过敏性疾病的理解形成鲜明对比的是，非IgE介导的过敏性疾病或非IgE介导的疾病所涉及的机制几乎没有解决，正在等待专门的研究人员来揭示。
Role of mast cells in allergy had remained undetermined until the discovery of IgE in 1966. Then, IgE purified from many Liters of plasma, which had been donated from a patient with fatal myeloma, was distributed to researchers all over the world, and thus accelerated exploring the mechanisms involved in allergic reactions, particularly about the role of mast cells and basophils in the IgE-mediated reactions. Identification of mast cells as a progeny of a bone marrow hematopoietic stem cell in 1977 led us to successful in vitro culture of human mast cells. Along with the development of molecular biological techniques, the structure of the high affinity IgE receptor (FcεRI) was determined in 1989. These findings and subsequent investigations brought deeper understanding of IgE-mediated allergic diseases in the past half century, especially where mast cells are involved. We have now even obtained the information about whole genome expression of FcεRI-dependently activated mast cells. In sharp contrast to our comprehension of allergic diseases where IgE and mast cells are involved, the mechanisms involved in non-IgE-mediated allergic diseases or non-IgE-mediated phase of IgE-mediated diseases are almost left unsolved and are waiting for devoted investigators to reveal it.
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影响因子：
14.2
作者：
Dougherty, Ryan H.;Sidhu, Sukhvinder S.;Raman, Kavita;Solon, Margaret;Solberg, Owen D.;Caughey, George H.;Woodruff, Prescott G.;Fahy, John V.
通讯作者：
Fahy, John V.
影响因子：
14.2
作者：
Nakajima, T;Iikura, M;Saito, H
通讯作者：
Saito, H
影响因子：
4.4
作者：
F. Levi‐Schaffer;K. Austen;J. Caulfield;A. Hein;P. M. Gravallese;R. Stevens
通讯作者：
F. Levi‐Schaffer;K. Austen;J. Caulfield;A. Hein;P. M. Gravallese;R. Stevens
影响因子：
6
作者：
Piliponsky, Adrian M.;Chen, Ching-Cheng;Galli, Stephen J.
通讯作者：
Galli, Stephen J.
小鼠骨髓来源的肥大细胞与成纤维细胞共培养。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Levi-Schaffer,F;Dayton,ET;Austen,KF;Hein,A;Caulfield,JP;Gravallese,PM;Liu,FT;Stevens,RL
通讯作者：
Stevens,RL