Demonstration of the dynamic nature of idiopathic hypertrophic subaortic stenosis.
Demonstration of the dynamic nature of idiopathic hypertrophic subaortic stenosis.
复制标题
展示特发性肥厚性主动脉瓣下狭窄的动态性质。
DOI：
10.1016/0002-9149(63)90025-0
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
Henry D. Mcintosh
中科院分区：
文献类型：
--
作者：
R. E. Whalen;A. I. Cohen;Robert G. Sumner;Henry D. Mcintosh
异丙肾上腺素输注在15分钟内将一名潜在的肥厚性主动脉瓣下狭窄患者转变为一名具有重度肥厚性主动脉瓣下狭窄所有血流动力学特征的患者。在15例各种原因引起的左心室肥厚患者中，在输注异丙肾上腺素期间未观察到这种反应，需要进一步研究这种药物在病因不明的左心室肥厚患者中的作用。输注异丙肾上腺素可作为一种激发试验，以识别早期或潜伏型肥厚性主动脉瓣下狭窄的患者。这样的研究也将允许在症状和体征变得如此严重以至于无法进行广泛的调查之前，对综合征的血流动力学特征进行更仔细的检查。
Isoproterenol infusion converted a patient with potential hypertrophic subaortic stenosis into one with all the hemodynamic features of severe hypertrophic subaortic stenosis in less than 15 minutes. This response was not observed during isoproterenol infusion in 15 patients with left ventricular hypertrophy from a variety of causes.Further study of this drug in patients with left ventricular hypertrophy of unknown etiology is indicated. Infusion of isoproterenol may serve as a provocative test to identify those patients with early or latent forms of hypertrophic subaortic stenosis. Such studies will also allow a more careful examination of the hemodynamic features of the syndrome before the signs and symptoms have become so severe as to preclude extensive investigation.