Asymmetric Construction of α,γ-Disubstituted α,β-Butenolides Directly from Allylic Ynoates Using a Chiral Bifunctional Phosphine Ligand Enables Cooperative Au Catalysis.
Asymmetric Construction of α,γ-Disubstituted α,β-Butenolides Directly from Allylic Ynoates Using a Chiral Bifunctional Phosphine Ligand Enables Cooperative Au Catalysis.
复制标题
DOI：
10.1021/acs.orglett.2c01652
复制
发表时间：
2022-06
期刊：
影响因子：
5.2
通讯作者：
Ting Li;Shicheng Dong;Conghui Tang;Meiling Zhu;Nan Wang;W. Kong;Wenchao Gao;Jun Zhu;Liming Zhang
中科院分区：
文献类型：
--
作者：
Ting Li;Shicheng Dong;Conghui Tang;Meiling Zhu;Nan Wang;W. Kong;Wenchao Gao;Jun Zhu;Liming Zhang
实现了从容易获得的烯丙基炔酸酯高效地构建手性γ-取代的α-烯丙基-α，β-丁烯内酯，其具有高达>99%的对映体过量。在这种不对称金催化中，以双官能膦配体为特征的阳离子金（I）催化剂能够实现四步级联，其允许将各种各样的烯丙基炔酸酯转化为有价值的手性α，γ-二取代的α，β-丁烯内酯。
A highly efficient construction of chiral γ-substituted α-allyl-α,β-butenolides with up to >99% enantiomeric excess from readily available allylic ynoates is realized. In this asymmetric gold catalysis, the cationic gold(I) catalyst featuring a bifunctional phosphine ligand enables a four-step cascade which permits the conversion of a diverse array of allylic ynoates into valuable chiral α,γ-disubstituted α,β-butenolides.