Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism
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Pygo1 通过 β-cantenin 依赖机制调节病理性心脏肥大
DOI：
10.1152/ajpheart.00538.2020
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Jian Zhuang
中科院分区：
文献类型：
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作者：
Li Lin;Wei Xu;Yongqing Li;Ping Zhu;Wuzhou Yuan;Ming Liu;Yan Shi;Yu Chen;Jifeng Liang;Jimei Chen;Boyu Yang;Wanwan Cai;Yao Wen;Xiaolan Zhu;Xiyang Peng;Zuoqiong Zhou;Xiaoyang Mo;Yongqi Wan;Hai-Yun Yuan;Fang Li;Xiangli Ye;Zhigang Jiang;Yuequn Wang;Jian Zhuang
Pygo 1在哺乳动物心脏疾病中的作用尚未阐明。在这项研究中，我们发现Pygo 1与人类病理性肥大有关。心脏特异性过表达Pygo 1的小鼠自发地导致心脏肥大，伴随着心脏功能下降，心脏重量/体重和心脏重量/胫骨长度比增加，以及细胞大小增加。同时，干预Pygo 1表达可改善肥厚模型小鼠的心功能。我们的研究是第一个提出体内证据证明Pygo 1以典型的Wnt/β-catenin依赖性方式调节病理性心脏肥大，这可能为靶向该途径的组织特异性临床治疗提供新的线索。
The role of Pygo1 in mammalian cardiac disease remains unelucidated. In this study, we found that Pygo1 is associated with human pathological hypertrophy. Cardiac-specific overexpression of Pygo1 in mice spontaneously led to cardiac hypertrophy, accompanied by declined cardiac function, increased heart weight/body weight and heart weight/tibial length ratios, and increased cell size. Meanwhile, cardiac function was improved when expression of Pygo1 interfered in hypertrophy-model mice. Our study is the first to present in vivo evidence demonstrating that Pygo1 regulates pathological cardiac hypertrophy in a canonical Wnt/β-catenin-dependent manner, which may provide new clues for a tissue-specific clinical treatment targeting this pathway.