Synthesis of 2-vinylic indoles and derivatives via a Pd-catalyzed tandem coupling reaction
Synthesis of 2-vinylic indoles and derivatives via a Pd-catalyzed tandem coupling reaction
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DOI：
10.1021/ol061374l
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发表时间：
2006-09-14
期刊：
影响因子：
5.2
通讯作者：
Lautens, Mark
中科院分区：
文献类型：
--
作者：
Fayol, Aude;Fang, Yuan-Qing;Lautens, Mark
描述了一种有价值的 2-乙烯基吲哚及其三环衍生物的新型一步合成方法。该反应利用偕二溴乙烯基单元作为易于获得的起始原料，通过有效的 Pd 催化串联 Buchwald-Hartwig/Heck 反应发生。
A novel one-step synthesis of valuable 2-vinylic indoles and their tricycle derivatives is described. This reaction, which utilizes a gemdibromovinyl unit as a readily available starting material, occurs via an efficient Pd-catalyzed tandem Buchwald-Hartwig/Heck reaction.