Association between hepatitis C virus infection and diabetes mellitus.
Association between hepatitis C virus infection and diabetes mellitus.
复制标题
丙型肝炎病毒感染与糖尿病之间的关联。
DOI：
10.1093/oxfordjournals.epirev.a000808
复制
发表时间：
2001
影响因子：
5.5
通讯作者：
Thomas,DL
中科院分区：
文献类型：
--
作者：
Mehta,SH;Strathdee,SA;Thomas,DL
许多传染源与慢性疾病有关，包括人类免疫缺陷病毒与获得性免疫缺陷综合征、EB 病毒与伯基特淋巴瘤、人乳头瘤病毒与宫颈癌以及乙型肝炎病毒 (HBV) 与肝细胞癌的联系 (1-4)。生物学合理性和强有力的流行病学证据都被用来证明这些传染原引起了相关的慢性疾病。可以通过检测感染者中慢性病患病率的增加或慢性病患者中感染患病率的增加来建立流行病学关联。通过证实患病组织中的感染原可以加强生物学联系，但也可以通过观察感染和慢性疾病的病理生理学重叠特征来间接建立这种联系。丙型肝炎病毒（HCV）感染主要是一种肝脏疾病。然而，HCV 也与涉及其他几个器官和组织系统（包括肾脏和皮肤）的多种慢性病有关。对于其中一些疾病，有强有力的流行病学证据和生物学合理性，而对于其他疾病，只有流行病学证据。糖尿病就是这样一种慢性疾病，最近发现与丙型肝炎病毒感染有关。在过去 5 年中，至少有 22 篇报告支持 (n= 19)(19, 28-37, 40, 41, 45^ 7, 52-54) 或反驳 (n= 3)(38, 49, 50) 这两种情况之间的关联。然而，最近尚未对有关该主题及其潜在生物学机制的文献进行综述。本综述考虑了关于这两种常见病症之间因果关系的流行病学证据和生物学证据的现有文献。
A number of infectious agents have been linked to chronic diseases, including the linkages of human immunodeficiency virus with acquired immunodeficiency syndrome, Epstein-Barr virus with Burkitt's lymphoma, human papillomavirus with cervical cancer, and hepatitis B virus (HBV) with hepatocellular carcinoma (1-4). Both biologic plausibility and strong epidemiologic evidence were used to demonstrate that these infectious agents caused the associated chronic disease. Epidemiologic associations can be made by detecting either an increased prevalence of the chronic disease among persons with the infection or an increased prevalence of the infection among persons with the chronic disease. The biologic link is strengthened by demonstration of the infectious agent in the diseased tissues, but it can also be made indirectly by observation of overlapping features in the pathophysiology of the infection and the chronic disease.Hepatitis C virus (HCV) infection is mainly a disease of the liver. However, HCV has also been linked to a variety of chronic conditions involving several other organ and tissue systems, including the kidneys and skin. For some of these diseases, there is strong epidemiologic evidence and biologic plausibility, while for others there is only epidemiologic evidence. Diabetes mellitus is one such chronic condition that has recently been associated with HCV infection. In the past 5 years, at least 22 reports either supporting (n= 19)(19, 28-37, 40, 41, 45^ 7, 52-54) or refuting (n= 3)(38, 49, 50) an association between these two conditions have been published. However, the literature on this subject and the potential biologic mechanisms involved have not been recently reviewed. This review considers the existing literature with respect to both the epidemiologic evidence and the biologic evidence for a causal relation between these two common conditions.