Biogenic amine concentrations in the brains of normal and narcoleptic canines: current status.
Biogenic amine concentrations in the brains of normal and narcoleptic canines: current status.
复制标题
正常和发作性睡病犬脑中的生物胺浓度：现状。
作者：
Faull,KF;Zeller-DeAmicis,LC;Radde,L;Bowersox,SS;Baker,TL;Kilduff,TS;Dement,WC
神经药理学数据表明生物胺参与了发作性睡病。例如，在人类中，增加突触裂隙中生物胺浓度的药物可以改善发作性睡病的症状。因此，阻断单胺再摄取的药物(如三环抗抑郁药)、促进单胺释放的药物(如哌酸甲酯)或抑制单胺氧化酶的药物具有治疗效果(1，2)。对遗传型和非遗传型犬病的药理学实验证实了这些发现(3-5)。在之前的工作中，我们比较了从正常狗和成年小型法国贵宾犬脑池中收集的单胺代谢物浓度与非遗传性但严重的发作性睡病。受影响动物的脑脊液中多巴胺和5-羟色胺代谢产物的稳态浓度较低，使用酸运输抑制剂丙磺舒收集的数据表明，5-羟色胺和去甲肾上腺素的周转减少(6)。这些结果提示发作性睡病动物的单胺代谢异常，并导致我们对发作性睡病动物和正常动物进行了区域神经化学研究。
Neuropharmacological data suggest involvement of the biogenic amines in narcolepsy. In humans, for example, drugs that increase biogenic amine concentrations in the synaptic cleft ameliorate symptoms of narcolepsy. Thus, agents that block monoamine reuptake (e.g., tricyclic antidepressants), potentiate monoamine release (e.g., methylphenidate), or inhibit monoamine oxidase possess therapeutic efficacy (1,2). Pharmacological experiments with genetic and nongenetic forms of the canine disease confirm these findings (3-5).In previous work, we compared monoamine metabolite concentrations in cisternal cerebrospinal fluid (CSF) collected from normal dogs and from adult miniature French poodles with a nongenetic but severe form of narcolepsy. Steady-state concentrations of dopamine and serotonin metabolites were lower in the CSF of the affected animals, and data collected with the use of the acid transport inhibitor probenecid suggested reduced turnover of serotonin and norepinephrine (6). These results suggested an abnormality in monoamine metabolism in the narcoleptic animals, and led us to undertake regional neurochemical studies in narcoleptic and normal animals.