Bilingual aphasia and language control: A follow-up fMRI and intrinsic connectivity study
Bilingual aphasia and language control: A follow-up fMRI and intrinsic connectivity study
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DOI：
10.1016/j.bandl.2009.03.003
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发表时间：
2009-05-01
影响因子：
2.5
通讯作者：
Cappa, Stefano F.
中科院分区：
文献类型：
--
作者：
Abutalebi, Jubin;Della Rosa, Pasquale Anthony;Cappa, Stefano F.
在一个多语言化的世界中，双语失语症是一个具有重大临床影响的临床问题。然而，目前我们缺乏对恢复模式的许多特征的因果解释，并且对于患者应该接受言语治疗的语言也没有达成共识。进一步的进步需要了解复苏的动态。在一项新颖的纵向单病例研究中，我们结合功能磁共振成像和动态因果模型来检查图像命名的特定语言治疗对恢复过程中语言区域的表征和控制的影响。所处理语言的表现改善与语言区域激活的增加有关。与理论预期一致，因果模型表明处理语言的控制网络和语言网络的连通性增强。这种功能性方法对于研究双语失语症患者的恢复模式和特定语言治疗的效果具有广阔的前景。 (C) 2009 Elsevier Inc. 保留所有权利。
In a world that is becoming more multilingual, bilingual aphasia is a clinical problem with a major clinical impact. However, at present we lack causal explanations of the many features of recovery patterns and there is no consensus about the language in which the patient should receive speech therapy. Further advance requires an understanding of the dynamics of recovery. In a novel longitudinal, single-case study, we combine fMRI and dynamic causal modeling to examine the effects of specific language treatment for picture naming on the representation and control of language areas during the course of recovery. Improved performance in the treated language was associated with increased activation in language areas. Consistent with theoretical expectations, causal modeling indicated increased connectedness of the control and language networks for the treated language. This functional approach holds great promise for investigating recovery patterns and the effects of specific language treatment in bilingual aphasic patients. (C) 2009 Elsevier Inc. All rights reserved.