Long-term effect of bilateral anterior elevation of occlusion on the temporomandibular joints
Long-term effect of bilateral anterior elevation of occlusion on the temporomandibular joints
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DOI：
10.1111/odi.13914
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发表时间：
2021-05-30
期刊：
影响因子：
3.8
通讯作者：
Wang, Meiqing
中科院分区：
文献类型：
--
作者：
Zhang, Yuejiao;Liu, Qian;Wang, Meiqing
目的研究双侧前抬高（BAE）关系的切牙管型修复体对小鼠髁突软骨的增殖反应，从而提出修复体抬高治疗髁突软骨退变的方法。材料与方法12只6周龄雌性小鼠随机分为对照组和BAE组，每组6只。结果BAE组髁突上级部位软骨下皮质骨丢失，软骨下骨小梁严重丢失，髁突下部骨质增生。BAE组软骨厚度和基质面积增加，II型胶原、X型胶原和Ki 67表达上调，而caspase-3表达下调（均p < 0.05）。结论长期BAE除导致软骨增厚外，还导致软骨下皮质骨丢失，软骨下松质骨严重丢失，软骨下骨质增生。使用BAE作为治疗方法仍然是双刃剑。
Objective Incisors tubed prosthesis with bilateral anterior elevation (BAE) relation had been reported to stimulate the proliferative response in the mandibular condylar cartilage of mice, thus the prosthetic occlusion elevation had been proposed to treat cartilage degeneration. Currently, we aimed to detect the long-term effect of BAE on temporomandibular joints (TMJs).Materials and Methods Twelve 6-week-old female mice were assigned to age-matched control and BAE groups (n = 6). Micro-CT images and the macro- and micro-morphology of the mandibular condyles were analyzed at 29 weeks.Results Compared with the age-matched controls, in BAE group, there were loss of subchondral cortical bone and heavy loss of the subchondral trabecular bone at the superior sites of the TMJ condyles, but hyperostosis at the inferior sites as revealed by micro-CT images and histological slices. In BAE group, cartilage thickness and matrix area were increased with upregulated expression of type II, type X collagen, and Ki67, but the expression of cleaved caspase-3 was downregulated (all, p < 0.05).Conclusion In addition to cartilage thickening, long-term BAE induces loss of the subchondral cortical bone and heavy loss of the underneath subchondral trabecular bone, but hyperostosis further underneath. Using BAE as a treatment remains double-edged.