Runx Family Genes in Tissue Stem Cell Dynamics.
Runx Family Genes in Tissue Stem Cell Dynamics.
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DOI：
10.1007/978-981-10-3233-2_9
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发表时间：
2017
影响因子：
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通讯作者：
Chelsia Qiuxia Wang;Michelle Meng Huang Mok;T. Yokomizo;V. Tergaonkar;Motomi Osato
中科院分区：
文献类型：
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作者：
Chelsia Qiuxia Wang;Michelle Meng Huang Mok;T. Yokomizo;V. Tergaonkar;Motomi Osato
Runx家族基因在发育和癌症中起着重要作用，主要是通过它们对组织干细胞行为的调节。他们参与两个器官，血液和皮肤，是有据可查的。本文综述了目前已知的Runx功能在这些组织的干细胞。介导的基本核心机制 然而，似乎不存在一种单一的共同机制来管理两种组织干细胞。相反，Runx家族基因在调节个体组织干细胞群体中采用多种时空机制。这种特定的Runx要求已经在小鼠中的一系列细胞类型，发育阶段或年龄特异性基因靶向研究中揭示。这些实验的观察结果表明，Runx家族基因对干细胞的调控比以前想象的要复杂得多。例如，尽管已经报道Runx1是内皮细胞向造血细胞转化（EHT）所需的，但此后不是，最近的研究清楚地表明，Runx1在EHT之后的时期，即在围产期也是需要的。此外，Runx1在胚胎皮肤间充质中的消融最终导致成年上皮中毛囊干细胞（HFSC）的完全丧失，这表明Runx1以细胞外在方式促进皮肤上皮干细胞的特化。需要进一步深入研究Runx家族基因如何参与干细胞调控。
The Runx family genes play important roles in development and cancer, largely via their regulation of tissue stem cell behavior. Their involvement in two organs, blood and skin, is well documented. This review summarizes currently known Runx functions in the stem cells of these tissues. The fundamental core mechanism(s) mediated by Runx proteins has been sought; however, it appears that there does not exist one single common machinery that governs both tissue stem cells. Instead, Runx family genes employ multiple spatiotemporal mechanisms in regulating individual tissue stem cell populations. Such specific Runx requirements have been unveiled by a series of cell type-, developmental stage- or age-specific gene targeting studies in mice. Observations from these experiments revealed that the regulation of stem cells by Runx family genes turned out to be far more complex than previously thought. For instance, although it has been reported that Runx1 is required for the endothelial-to-hematopoietic cell transition (EHT) but not thereafter, recent studies clearly demonstrated that Runx1 is also needed during the period subsequent to EHT, namely at perinatal stage. In addition,Runx1ablation in the embryonic skin mesenchyme eventually leads to complete loss of hair follicle stem cells (HFSCs) in the adult epithelium, suggesting that Runx1 facilitates the specification of skin epithelial stem cells in a cell extrinsic manner. Further in-depth investigation into how Runx family genes are involved in stem cell regulation is warranted.