Karyotypic abnormalities in tumours of the pancreas.
Karyotypic abnormalities in tumours of the pancreas.
复制标题
胰腺肿瘤的核型异常。
作者：
G. Bardi;B. Johansson;N. Pandis;N. Pandis;N. Mandahl;E. Bak‐Jensen;Åke Andrén‐Sandberg;F. Mitelman;S. Heim
对20例胰腺肿瘤的短期培养进行了细胞遗传学分析，其中内分泌肿瘤3例，外分泌肿瘤17例。这三种内分泌肿瘤的染色体都是正常的。在17例外分泌肿瘤中有13例检测到克隆性染色体异常，其中5例发现简单的核型改变，8例发现大量的数目和/或结构改变。将本研究结果与本课题组以前报道的结果结合起来看，可用于评估的22例核型异常胰腺癌中最常见的数值失衡结果是，按频率下降的顺序依次为-18、-Y、+20、+7、+11和-12。结构性变化带来的失衡最常影响到1号染色体(1p的损失，但特别是1q的收益)、8号染色体(特别是8q的收益)和17号染色体(主要是17q的收益，但也有17p的损失)。染色体1p32、1q10、6q21、7p22、8p21、8q11、14p11、15q10-11和17q11是受结构重排影响最常见的断裂点。核型异常在低分化癌和间变性癌中比在中分化和高分化肿瘤中更常见。
Short-term cultures from 20 pancreatic tumours, three endocrine and 17 exocrine, were cytogenetically analysed. All three endocrine tumours had a normal chromosome complement. Clonal chromosome aberrations were detected in 13 of the 17 exocrine tumours: simple karyotypic changes were found in five carcinomas and numerous numerical and/or structural changes in eight. When the present findings and those previously reported by our group were viewed in conjunction, the most common numerical imbalances among the 22 karyotypically abnormal pancreatic carcinomas thus available for evaluation turned out to be, in order of falling frequency, -18, -Y, +20, +7, +11 and -12. Imbalances brought about by structural changes most frequently affected chromosomes 1 (losses in 1p but especially gains of 1q), 8 (in particular 8q gains but also 8p losses), and 17 (mostly 17q gain but also loss of 17p). Chromosomal bands 1p32, 1q10, 6q21, 7p22, 8p21, 8q11, 14p11, 15q10-11, and 17q11 were the most common breakpoint sites affected by the structural rearrangements. Abnormal karyotypes were detected more frequently in poorly differentiated and anaplastic carcinomas than in moderately and well differentiated tumours.
子宫内膜癌中 1 号染色体长臂的标记染色体。
影响因子：
--
作者：
Fujita,H;Wake,N;Kutsuzawa,T;Ichinoe,K;Hreshchyshyn,MM;Sandberg,AA
通讯作者：
Sandberg,AA
影响因子：
16.6
作者：
M. Barbacid
通讯作者：
M. Barbacid
检测人胰腺腺癌细针抽吸物中的 c-K-ras 突变。
影响因子：
11.2
作者：
Shibata,D;Almoguera,C;Forrester,K;Dunitz,J;Martin,SE;Cosgrove,MM;Perucho,M;Arnheim,N
通讯作者：
Arnheim,N