A general method of halogenation for synthesis of α-halodifluoromethyl ketones and [18F]-labeled trifluoromethyl ketones
A general method of halogenation for synthesis of α-halodifluoromethyl ketones and [18F]-labeled trifluoromethyl ketones
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DOI：
10.1016/s0022-1139(03)00039-3
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发表时间：
2003-06-01
影响因子：
1.9
通讯作者：
Olah, GA
中科院分区：
文献类型：
--
作者：
Prakash, GKS;Hu, JB;Olah, GA
本文报道了一种简便的合成α-卤代二氟甲基酮的通用卤化方法。2，2-二氟-1-芳基-1-三甲基异丁烯（二氟甲硅烷基烯醇醚）（2a-e）与卤素在低温（-30 ℃至-78 ℃）下反应产生高产率的α-卤代二氟甲基酮（la-j）。这种一步简单的方法对于合成[F-18]-标记的α-三氟甲基酮是非常有用的。Alpha 2003 Elsevier Science B. V.保留所有权利。
A convenient general method of halogenations suitable for synthesis of alpha-halodifluoromethyl ketones is reported. Reaction of 2,2-difluoro-1-aryl-1-trimethylsiloxyethenes (difluoro silyl enol ethers) (2a-e) with halogens at low temperature (-30 to -78degreesC) produced a high yield of alpha-halodifluoromethyl ketones (la-j). This one-step simple method can be highly useful for synthesis of [F-18]-labeled alpha-trifluoromethyl ketones. alpha 2003 Elsevier Science B.V. All rights reserved.