CuInS2 quantum dots/poly(L-glutamic acid)-drug conjugates for drug delivery and cell imaging
CuInS2 quantum dots/poly(L-glutamic acid)-drug conjugates for drug delivery and cell imaging
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DOI：
10.1039/c3an01134h
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发表时间：
2014-01-01
期刊：
影响因子：
4.2
通讯作者：
Su, Xingguang
中科院分区：
文献类型：
--
作者：
Gao, Xue;Liu, Ziping;Su, Xingguang
基于带正电荷的CuInS 2量子点（QDs）和带负电荷的聚谷氨酸（PGA）的静电复合物与抗癌模型药物阿霉素（DOX）的偶联，开发了一种新型的抗癌药物传递系统。采用水热法直接合成了L-半胱氨酸修饰的水溶性近红外CuInS 2量子点。DOX可以通过光诱导电子转移过程猝灭QDs/PGA-DOX纳米颗粒中CuInS 2量子点的光致发光，从而使CuInS 2量子点处于荧光“关闭”状态。在QD/PGA-DOX纳米颗粒暴露于羧肽酶或被癌细胞吸收后，PGA被水解以释放DOX，诱导CuInS 2 QD荧光激活至“开启”状态。量子点/PGA-DOX纳米粒子可以将DOX递送到靶向癌细胞，并基于CuInS 2量子点的荧光“开启”信号监测DOX释放，这可以同时用于癌细胞的成像。多功能量子点/PGA-DOX纳米粒在肿瘤治疗的临床应用方面具有巨大的潜力。
A new anticancer drug delivery system was developed based on the electrostatic complex of positively charged CuInS2 quantum dots (QDs) and negatively charged poly(L-glutamic acid) (PGA) conjugated with the model anticancer drug doxorubicin (DOX). Water-soluble near-infrared CuInS2 QDs capped with L-cysteine were directly synthesized by a hydrothermal method. DOX can quench the photoluminescence of CuInS2 QDs in QDs/PGA-DOX nanoparticles through a photoinduced electron transfer process, thus CuInS2 QDs are in the fluorescence "turn-off" state. After the QDs/PGA-DOX nanoparticles are exposed to carboxypeptidase or are taken up by cancer cells, PGA is hydrolysed to release DOX, inducing activation of the CuInS2 QDs fluorescence to the "turn-on" state. The QDs/PGA-DOX nanoparticles can deliver DOX to targeted cancer cells and monitor the DOX release based on the fluorescence "turn-on" signal of CuInS2 QDs, and this could be simultaneously used for the imaging of cancer cells. The multifunctional QDs/PGA-DOX nanoparticles have great potential in terms of their clinical application for cancer therapy.