The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial
The pilot study: Sphingomyelin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial
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DOI：
10.1016/j.braindev.2012.03.004
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发表时间：
2013-01-01
影响因子：
1.7
通讯作者：
Shimizu, T.
中科院分区：
文献类型：
--
作者：
Tanaka, K.;Hosozawa, M.;Shimizu, T.
目的：本研究是一项随机对照试验，旨在研究鞘磷脂(SM)对早产儿智力、运动和行为发育的影响。患者和方法：随机、双盲对照试验，纳入2004年1月至2007年10月在Juntendo大学医院出生体重小于1500 g的婴儿，随访18个月。24名早产儿被随机分配；12名早产儿被分配到试验组，饲喂SM强化牛奶(SM占牛奶中所有磷脂的20%)，12名分配给对照组(SM占牛奶中所有磷脂的13%)。分析血浆磷脂和红细胞膜脂肪酸的组成，然后进行VEP、Fagan、BSID-II、注意力和记忆力测试。结果：在第4、6、8周，试验组SM占总磷脂的百分比显著高于对照组。18个月时BSID-II行为评定量表、Fagan测验分数、VEP潜伏期、持续注意力测验分数，试验组均明显优于对照组。结论：本研究首次报道了添加SM强化奶的营养干预与低出生体重儿的神经行为发育呈正相关。然而，还需要对SM对长期发展的影响进行详细研究。(C)2012年日本儿童神经病学学会。爱思唯尔出版，版权所有。
Aim: This study was a randomised control trial to examine the effects of sphingomyelin (SM), on the mental, motor and behavioural development of premature infants. Patients and methods: Randomised, double-blind controlled trial, enroling infants born with a birth weight of less than 1500 g between January 2004 and October 2007 at Juntendo University Hospital, with follow-up to 18 months. Twenty-four preterm babies were randomly assigned; 12 were assigned to a test group and fed SM-fortified milk (SM 20% of all phospholipids in milk) and 12 were assigned to a control group (SM 13% of all phospholipids in milk). We analysed the composition of the plasma phospholipids and red-cell-membrane fatty acids, after which VEP, Fagan, BSID-II, attention and memory tests were performed. Results: The percentage of SM in the total phospholipids was significantly higher in the trial group than in the control group at 4, 6 and 8 weeks. The Behaviour Rating Scale of the BSID-II, the Fagan test scores, the latency of VEP, and sustained attention test scores at 18 months were all significantly better in the trial group than in the control group. Conclusion: This study is the first to report that nutritional intervention via administration of SM-fortified milk has a positive association with the neurobehavioural development of low-birth-weight infants. However, detailed studies on the effects of SM on longer-term development are required. (C) 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.