MATING AND AGONISTIC BEHAVIOR PRODUCE DIFFERENT PATTERNS OF FOS IMMUNOLABELING IN THE MALE SYRIAN-HAMSTER BRAIN
MATING AND AGONISTIC BEHAVIOR PRODUCE DIFFERENT PATTERNS OF FOS IMMUNOLABELING IN THE MALE SYRIAN-HAMSTER BRAIN
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DOI：
10.1016/0306-4522(94)00563-k
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发表时间：
1995-06-01
期刊：
影响因子：
3.3
通讯作者：
NEWMAN, SW
中科院分区：
文献类型：
--
作者：
KOLLACKWALKER, S;NEWMAN, SW
先前的研究表明，交配诱导了雄性叙利亚仓鼠大脑化学感觉通路中Fos蛋白的表达。然而，目前尚不清楚这种标记模式是特定于交配还是一般社会互动的结果。为了确定这些通路中激活的行为特异性，将交配后的Fos免疫染色与随后的激励性行为进行了比较。交配和竞争行为都依赖于化学感觉线索(15，52，72)和性腺类固醇(见参考文献，65)，而属于嗅觉和犁鼻通路的区域处理化学感觉和激素信息(见参考文献)。48)。这项研究的结果表明，在这两种社交行为之后，大脑激活模式既有相似之处，也有不同之处。兴奋性行为增加了杏仁内侧核、终纹前内侧和后中间床核、腹外侧隔核和下丘脑腹侧乳头体前核内Fos免疫反应阳性神经元的数量，其模式与交配后相似。这种交配和竞争行为常见的激活模式可能反映了动物在社会互动过程中总体唤醒状态的增加。相反，虽然交配和激动性行为都激活了杏仁内侧核尾侧亚区、终纹后内侧床核的背侧水平以及下丘脑室旁核和腹内侧核的神经元，但Fos免疫反应阳性神经元的分布和/或数量有所不同。此外，激动性行为选择性地激活终纹前外侧床核、下丘脑前核和中脑导水管周围灰质背侧，而交配单独激活终纹后内侧床核后腹侧水平和视前内侧区神经元。在争斗行为下的优势和从属雄性之间没有发现差异。这些观察和其他实验室的结果表明，交配和竞争行为激活了不同的神经回路。
Previous work has shown that mating induces the expression of Fos protein within the chemosensory pathways of the male Syrian hamster brain.(37) However, it is not known if this pattern of labeling is specific to mating or the result of social interactions in general. To determine the behavioral specificity of activation within these pathways, Fos immunostaining following mating was compared to that following agonistic behavior. Both mating and agonistic behavior are dependent upon chemosensory cues(15,52,72) and gonadal steroids (reviewed in Refs 64, 65) and areas belonging to the olfactory and vomeronasal pathways process chemosensory and hormonal information (reviewed in Ref. 48). The results of this study demonstrate both similarities and differences in brain activation patterns following these two social behaviors. Agonistic behavior increased the number of Fos-immunoreactive neurons within most subdivisions of the medial amygdala, the anteromedial and posterointermediate bed nucleus of the stria terminalis, the ventrolateral septum and the ventral premammillary nucleus of the hypothalamus in a pattern comparable to that observed after mating. This pattern of activation common to mating and agonistic behavior may reflect an increase in an animal's general state of arousal during social interactions. In contrast, although mating and agonistic behavior both activated neurons within the caudal subdivision of the medial nucleus of the amygdala, the anterodorsal level of posteromedial bed nucleus of the stria terminalis and the paraventricular and ventromedial nuclei of the hypothalamus, in these areas either the distribution and/or number of Fos-immunoreactive neurons differed. In addition, agonistic behavior selectively activated neurons within the anterolateral bed nucleus of the stria terminalis, the anterior nucleus of the hypothalamus and the dorsal periaqueductal gray, whereas mating alone activated neurons within the posteroventral level of posteromedial bed nucleus of the stria terminalis and the medial preoptic area. No differences were found between dominant and subordinate males following agonistic behavior. These observations along with results from other laboratories suggest that mating and agonistic behavior activate distinct neural circuits.