Novel Rapid Prototyping Method to Fabricate Poly (lactide-co-glycolide) Scaffold with High Porosity
Novel Rapid Prototyping Method to Fabricate Poly (lactide-co-glycolide) Scaffold with High Porosity
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发表时间：
2010
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通讯作者：
Jin Le
中科院分区：
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作者：
Jin Le
提出了一种基于快速成型（RP）技术制备具有三级孔、高孔隙率和连通大孔的支架的新方法，采用相分离和颗粒沥滤的方法，将颗粒均匀地混合到聚合物溶液中，然后通过体积驱动注射（VAI）喷嘴将浆料挤出到计算机设计的低温室中，然后在低温室中制备具有宏观结构的冷冻支架。通过溶剂和微粒的分别去除，可以得到孔径大于100 μ m的微孔，孔径小于10 μ m和10 ~ 100 μm的微孔，孔隙率大于90%，聚合物和微粒的浓度对浆料的孔隙率和粘度均有影响，因此，不同分子量的聚合物可通过VAI喷嘴加工得到高孔隙率的支架材料，制备了几种低分子量、高孔隙率的PLGA软骨组织工程支架材料。
A novel method is proposed to fabricate scaffolds with three-grade pores,high porosity and interconnected macro-pores.It is based on rapid prototyping (RP),phase separation and particulate leaching.The particulate is mixed into polymer solution homogeneously.And then the slurry is extruded into a low-temperature room as designed in the computer by a volume-actuated injecting (VAI) nozzle.Then a frozen scaffold with macro-pores more than 100 μm in diameter is obtained.Micro-pores less than 10 μm and between 10 μm and 100 μm in diameter also can be obtained by the respective removal of solvent and particulate.The porosity is higher than 90%.The concentration of polymer and particulate can influence both the porosity and viscosity of the slurry.Therefore,polymer with different molecular weight can be processed by the VAI nozzle to get a high-porosity scaffold.Several poly(Lactide-co-glycolide) (PLGA) scaffolds with low molecular weight and high porosity are fabricated for cartilage tissue engineering.