Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot
Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot
复制标题
酶和光氧化还原顺序催化一锅合成1,3-恶嗪衍生物
DOI：
10.1039/c6cy02682f
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发表时间：
2017
影响因子：
5
通讯作者：
He Yan-Hong
中科院分区：
文献类型：
--
作者：
Zhang Guo-Yan;Xiang Yang;Guan Zhi;He Yan-Hong
A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 1,3-oxazine derivatives from α- or β-naphthols and ethyl N-aryl glycinates is described for the first time. Various 1,3-oxazine derivatives were prepared with yields of up to 69% under mild reaction conditions by a simple operation. This approach consists of sequential enzymatic hydrolysis and visible-light excited decarboxylation of ethyl N-aryl glycinates, oxidation of α-amino radicals, Mannich reaction, transimination and intramolecular cyclization. This work provides a novel alternative method for the synthesis of 1,3-oxazine derivatives.
