Neural indicators of initial control rather than early maintenance of attention predict impaired visual attention in schizophrenia.
Neural indicators of initial control rather than early maintenance of attention predict impaired visual attention in schizophrenia.
复制标题
初始控制的神经指标而不是注意力的早期维持可预测精神分裂症患者的视觉注意力受损。
DOI：
10.1037/abn0000811
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Sponheim,ScottR
中科院分区：
文献类型：
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作者：
Lynn,PeterA;Sponheim,ScottR
长期以来，注意力过滤一直被认为是精神分裂症的核心缺陷。最近的研究强调了注意控制和执行选择之间的重要区别，前者涉及到自愿选择特定的刺激进行集中处理，后者涉及到通过过滤过程实际增强选择的刺激的机制。我们记录了精神分裂症患者（PSZ）、他们的一级亲属（REL）和健康对照（CTRL）在执行注意力捕获抵抗任务时的脑电图数据，该任务利用注意力控制和在短暂的注意力维持期间测量的选择的实施。注意控制和注意维持过程中的事件相关电位显示PSZ神经反应减弱。注意控制期间的erp对PSZ的视觉注意任务表现有预测作用，而对REL和CTRL没有预测作用。在注意维持阶段，erp最能预测CTRL的视觉注意表现。这些结果支持了一种观点，即精神分裂症患者的注意力功能障碍比难以实施选择（例如，保持注意力）更为重要。然而，表明PSZ早期注意力维持受损的弱神经调节挑战了该疾病中注意力强度增加或“过度聚焦”的概念。改善注意力的初始控制可能是精神分裂症认知补救干预的有效目标。（PsycInfo数据库记录(c) 2023 APA，版权所有）
Attentional filtering has long been suggested to be a core deficit of schizophrenia. Recent work has emphasized the important distinction between attentional control, which involves the voluntary selection of a particular stimulus for focused processing, and implementation of selection, which involves the mechanisms that actually enhance the stimulus selected via filtering processes. We recorded electroencephalography data from people with schizophrenia (PSZ), their first-degree relatives (REL) and healthy controls (CTRL) during performance of a resistance to attentional capture task that tapped attentional control and implementation of selection measured during a brief period of attentional maintenance. Event-related potentials (ERPs) during attentional control and maintenance of attention revealed diminished neural responding in PSZ. ERPs during attentional control predicted performance on the visual attention task for PSZ, but not for REL and CTRL. Visual attention performance for CTRL was best predicted by ERPs during attentional maintenance. These results support the idea that poor initial voluntary attentional control is more central to attentional dysfunction in schizophrenia than difficulty implementing selection (eg, maintaining attention). Nevertheless, weak neural modulations indicative of impaired early attentional maintenance in PSZ challenge notions of increased intensity of focus or “hyperfocusing” in the disorder. Improvement of the initial control of attention may be a productive target for cognitive remediation interventions for schizophrenia.(PsycInfo Database Record (c) 2023 APA, all rights reserved)