Age May Influence the Impact of TRAbs on Thyroid Function and Relapse-Risk in Patients With Graves Disease
Age May Influence the Impact of TRAbs on Thyroid Function and Relapse-Risk in Patients With Graves Disease
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DOI：
10.1210/jc.2018-01738
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发表时间：
2019-05-01
影响因子：
5.8
通讯作者：
Razvi, Salman
中科院分区：
文献类型：
--
作者：
Bano, Arjola;Gan, Earn;Razvi, Salman
背景：促甲状腺激素受体抗体(TRABS)在Graves病(GD)的发病机制中起重要作用。然而，影响TRAB与甲状腺激素和GD复发风险的关联的因素仍然不清楚。目的：我们调查了TRAB在诊断时与甲状腺激素和复发风险的关联，以及可能影响这些关联的潜在因素。设计和环境：英国一家内分泌中心的前瞻性研究。患者和主要结果衡量：连续384名GD患者在确诊时进行了TRABS和甲状腺激素的测定。结果：TRABS与甲状腺激素呈非线性相关，呈先正斜率后趋平的曲线(P
Context: Thyrotropin receptor antibodies (TRAbs) play a crucial role in the pathogenesis of Graves disease (GD). However, factors that influence the association of TRAbs with thyroid hormones and relapse risk in GD remain unclear.Objective: We investigated the associations of TRAbs at diagnosis with thyroid hormones and relapse risk and potential factors that can influence these associations in GD.Design and Setting: A prospective study in an endocrine center in England. Patients and Main OutcomeMeasures: Three hundred eighty-four consecutive patients with GD who had measurements of TRAbs and thyroid hormones at diagnosis. The association of TRAbs with thyroid hormones and relapse risk was assessed through linear regression and Cox proportional hazard models, adjusted for confounders.Results: TRAbs were nonlinearly associated with thyroid hormones, following a curve with an initial positive slope and a subsequent flattening (P