Waist circumference is strongly associated with renal resistive index in normoalbuminuric patients with type 2 diabetes
Waist circumference is strongly associated with renal resistive index in normoalbuminuric patients with type 2 diabetes
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DOI：
10.1159/000109239
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发表时间：
2008-01-01
影响因子：
4.2
通讯作者：
Cignarelli, Mauro
中科院分区：
文献类型：
--
作者：
Lamacchia, Olga;Nicastro, Vincenzo;Cignarelli, Mauro
目的：人体测量参数可能在调节肾功能不全的风险中发挥作用。本研究的目的是评估人体测量指标和代谢综合征是否与正常白蛋白尿的2型糖尿病（T2 DM）患者的肾阻力指数（RI）的变化相关。方法：连续招募99例T2 DM患者，其中男性76例，女性23例。用双功多普勒超声评估RI。结果如下：在单因素分析中，RI值与年龄之间存在显著相关性，（r = 0.507，p < 0.0001），性别（女性较高，p = 0.002），收缩压（r = 0.285，p = 0.011），吸烟习惯（当前吸烟者较低，p = 0.047），估计的肾小球滤过率（r =-0.435，p < 0.0001）;颈动脉内膜-中膜厚度（r = 0.271，p = 0.020）。就人体测量参数而言，发现腰围（WC; r = 0.401，p < 0.0001）、BMI（r = 0.337，p = 0.003）和RI值之间有很强的相关性，但在调整几个混杂因素后，只有WC保持显著相关性（p = 0.001）。结论：在正常白蛋白尿的T2 DM患者中，肾内血流动力学异常似乎主要与WC相关。版权所有（c）2007 S. Karger AG，巴塞尔。
Objective: Anthropometric parameters may play a role in modulating the risk of kidney dysfunction. The aim of this study was to evaluate whether anthropometric indices and the metabolic syndrome are associated with alterations of the renal resistive index (RI) in normoalbuminuric type 2 diabetic (T2DM) patients. Methods: A sample of 99 consecutively recruited patients with T2DM (76 male and 23 female) was examined. The RI was assessed by duplex Doppler sonography. Results: In univariate analysis, a significant association between the RI values and age (r = 0.507, p < 0.0001), gender (being higher in women, p = 0.002), systolic blood pressure (r = 0.285, p = 0.011), smoking habit (being lower in current smokers, p = 0.047), estimated glomerular filtration rate (r = - 0.435, p < 0.0001), and intima- media thickness of the carotid arteries (r = 0.271, p = 0.020) was observed. As far as anthropometric parameters are concerned, a strong correlation between waist circumference (WC; r = 0.401, p < 0.0001), BMI (r = 0.337, p = 0.003) and RI values was found but only WC maintained a significant correlation after adjusting for several confounders (p = 0.001). Conclusions: In normoalbuminuric T2DM patients, the intrarenal hemodynamic abnormalities seem primarily associated with WC. Copyright (c) 2007 S. Karger AG, Basel.