Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions
Increase of novel biomarkers for oxidative stress in patients with plasma cell disorders and in multiple myeloma patients with bone lesions
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DOI：
10.1007/s00011-012-0498-7
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发表时间：
2012-10-01
影响因子：
6.7
通讯作者：
Musolino, Caterina
中科院分区：
文献类型：
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作者：
Gangemi, Sebastiano;Allegra, Alessandro;Musolino, Caterina
蛋白质氧化在肿瘤疾病的发病机制中起着关键作用。在这项研究中，我们分析了未经治疗的多发性骨髓瘤（MM）患者和患有意义不明的单克隆丙种球蛋白病（MGUS）的患者的氧化应激。我们评估了血清晚期氧化蛋白产物（AOPP）、晚期糖基化终产物（AGEs）、单克隆丙种球蛋白病患者和对照组的血清AOPPs和S-亚硝基化水平。与对照组和MGUS受试者相比，MM患者的亚硝基化蛋白显著增加。此外，在MM患者中，有骨病变的患者中AOPP、AGEs和S-亚硝基化蛋白的水平显着高于无溶解性骨病变的患者。MM与氧化应激密切相关，进一步的研究可能会提供深入了解氧化应激与MM疾病发生和进展或MM并发症之间推定的因果关系的见解。
Protein oxidation plays a key role in the pathogenesis of oncological diseases. In this study, we analyzed the oxidative stress in untreated multiple myeloma (MM) patients and in patients affected by monoclonal gammopathy of uncertain significance (MGUS).We evaluated serum levels of advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs), and protein nitrosylation in patients with monoclonal gammopathy and in control subjects.Serum levels of AOPPs and S-nitrosylated proteins were significantly increased in MM patients in comparison to controls and to MGUS subjects. Moreover, in MM patients the levels of AOPPs, AGEs and S-nitrosylated proteins were significantly higher in patients with bone lesions compared with those without lytic bone lesions.MM is closely associated with oxidative stress and further investigation might provide an insight to understand a putative causal link between oxidative stress and MM disease onset and progression or MM complications.