Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
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DOI：
10.1016/j.jdermsci.2015.06.011
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发表时间：
2015-11-01
影响因子：
4.6
通讯作者：
Coto-Segura, Pablo
中科院分区：
文献类型：
--
作者：
Batalla, Ana;Coto, Eliecer;Coto-Segura, Pablo
背景资料：IL 17信号通路在银屑病（PsO）的发病机制中起重要作用，目的：探讨IL 17信号通路基因的变异是否与银屑病的发病风险相关，或对疾病严重程度和银屑病关节炎（PsA）的发病风险有影响。对580例银屑病患者和567例健康对照者进行6种单核苷酸多态性（SNPs）基因分型的横断面观察性研究在IL 17 RA（rs4819554，rs879577），IL17 A（rs7747909），IL17 F（rs763780、rs 2397084）和IL 17 E结果：IL 17 RA rs 4819554 G基因携带者在原发性肝癌患者中的频率显著高于对照组（P < 0.05（OR = 1.33，95%CI = 1.05-1.69; p = 0.017）。IL 17 RA rs 4819554 G等位基因和IL 17 F rs 2397084 TT基因型在Cw 6阳性患者中显著更常见（分别为p = 0.037和p = 0.010）。IL 17 E rs79877597 C等位基因在重度PsO患者中明显更常见（p = 0.010; OR = 2.42，95%CI = 1.23-4.76），CC基因型与关节炎的存在相关结论：IL 17 RA rs 4819554 SNP是PsO的危险因素。IL 17 E rs79877597 SNP是PsO疾病严重程度和PsA风险的修饰因子。(C)2015年日本皮肤病研究学会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Background: The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO).Objectives: To determine whether the variation at the IL17 pathway genes was linked to the risk for PsO or had an effect on disease severity and the risk for Psoriatic arthritis (PsA).Methods: Cross-sectional observational study of 580 psoriasis patients and 567 healthy controls who were genotyped for six single nucleotide polymorphisms (SNPs) in the IL17RA (rs4819554, rs879577), IL17A (rs7747909), IL17F (rs763780, rs2397084), and IL17E (rs79877597) genes.Results: We found significant higher frequencies of IL17RA rs4819554 G carriers among the patients (OR = 1.33, 95%CI = 1.05-1.69; p = 0.017). The IL17RA rs4819554 G allele and IL17F rs2397084 TT genotype were significantly more frequent among Cw6 positive patients (p = 0.037 and p = 0.010, respectively). The IL17E rs79877597C allele was significantly more common among patients with severe forms of PsO (p = 0.010; OR = 2.42, 95%CI = 1.23-4.76), and the CC genotype with the presence of arthritis (p = 0.032; OR = 1.50, 95%CI = 1.04-2.18).Conclusions: We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA. (C) 2015 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.