Whole-genome Sequencing Used to Investigate a Nationwide Outbreak of Listeriosis Caused by Ready-to-eat Delicatessen Meat, Denmark, 2014
Whole-genome Sequencing Used to Investigate a Nationwide Outbreak of Listeriosis Caused by Ready-to-eat Delicatessen Meat, Denmark, 2014
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DOI：
10.1093/cid/ciw192
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发表时间：
2016-07-01
影响因子：
11.8
通讯作者：
Ethelberg, Steen
中科院分区：
文献类型：
--
作者：
Jensen, Anne Kvistholm;Nielsen, Eva Moller;Ethelberg, Steen
背景资料。李斯特菌病是一种严重的食源性感染。李斯特菌病的暴发很少发生，但往往被证明很难解决。2014年6月，我们通过患者访谈和全基因组测序(WGS)检测和调查了丹麦的一次李斯特菌病暴发。我们对来自患者的单核细胞增多性李斯特菌分离株和来自即食食品的可用分离株进行了WGS，并使用单核苷酸多态(SNP)分析对它们进行了比较。1例患者为单核细胞增多性李斯特氏菌
Background. Listeriosis is a serious foodborne infection. Outbreaks of listeriosis occur rarely, but have often proved difficult to solve. In June 2014, we detected and investigated a listeriosis outbreak in Denmark using patient interviews and whole-genome sequencing (WGS).Methods. We performed WGS on Listeria monocytogenes isolates from patients and available isolates from ready-to-eat foods and compared them using single-nucleotide polymorphism (SNP) analysis. Case patients had L. monocytogenes with