Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society
Endocrine-Disrupting Chemicals and Public Health Protection: A Statement of Principles from The Endocrine Society
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DOI：
10.1210/en.2012-1422
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发表时间：
2012-09-01
期刊：
影响因子：
4.8
通讯作者：
Saal, F. S. Vom
中科院分区：
文献类型：
--
作者：
Zoeller, R. Thomas;Brown, T. R.;Saal, F. S. Vom
内分泌干扰化学物质（EDC）是一种外源性化学物质，或化学物质的混合物，可以干扰激素的任何方面的作用。EDC潜在的有害影响必须考虑到激素合成、分泌和作用的调节以及在整个生命周期中这些事件的调节的可变性。发生EDC暴露的发育年龄是理解其影响的关键考虑因素。由于内分泌系统在生命周期中表现出组织、细胞和受体特异性作用，EDC可以产生复杂的镶嵌效应。当在严格的指导方针的推动下，通过内分泌机制对毒性进行静态分析，以确定EDC并管理对人类和野生动物种群的风险时，这种复杂性造成了困难。我们建议采用基础内分泌学的原则来识别EDC并管理其对暴露人群的风险。我们强调发育阶段的重要性，特别是认识到暴露于假定的“安全”剂量的化学品可能会影响通常没有内源性激素暴露的生命阶段，从而强调极低剂量的EDC暴露可能具有强大和不可逆转的影响。最后，关于目前旨在检测推定EDC的项目，即内分泌干扰物筛查项目，我们提出建议，通过结合基本内分泌原理来加强该项目，以进一步了解复杂的EDC效应，特别是由于发育暴露。（内分泌学153:4097-4110,2012）
An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion, and actions and the variability in regulation of these events across the life cycle. The developmental age at which EDC exposures occur is a critical consideration in understanding their effects. Because endocrine systems exhibit tissue-, cell-, and receptor-specific actions during the life cycle, EDC can produce complex, mosaic effects. This complexity causes difficulty when a static approach to toxicity through endocrine mechanisms driven by rigid guidelines is used to identify EDC and manage risk to human and wildlife populations. We propose that principles taken from fundamental endocrinology be employed to identify EDC and manage their risk to exposed populations. We emphasize the importance of developmental stage and, in particular, the realization that exposure to a presumptive "safe" dose of chemical may impact a life stage when there is normally no endogenous hormone exposure, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects. Finally, with regard to the current program designed to detect putative EDC, namely, the Endocrine Disruptor Screening Program, we offer recommendations for strengthening this program through the incorporation of basic endocrine principles to promote further understanding of complex EDC effects, especially due to developmental exposures. (Endocrinology 153: 4097-4110, 2012)