A TROJAN HORSE MECHANISM FOR THE SPREAD OF VISNA VIRUS IN MONOCYTES
A TROJAN HORSE MECHANISM FOR THE SPREAD OF VISNA VIRUS IN MONOCYTES
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DOI：
10.1016/0042-6822(85)90246-6
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发表时间：
1985-01-01
期刊：
影响因子：
3.7
通讯作者：
VENTURA, P
中科院分区：
文献类型：
--
作者：
PELUSO, R;HAASE, A;VENTURA, P
维斯纳病毒是逆转录病毒慢病毒亚科的原型，可引起绵羊和山羊的慢性感染。这些病毒持续存在，尽管有中和抗体，但可以从血液和脑脊液中分离多年。在这里报道的研究中，我们使用定量原位杂交来分析感染的白细胞。我们发现（1）单核细胞携带visna基因组;（2）病毒基因表达在该细胞中与在神经胶质细胞和上皮细胞中一样受到限制。 这些结果与病毒在免疫应答宿主中传播的特洛伊木马机制雅阁。
Visna virus is the prototype of the lentivrus subfamily of retroviruses that cause slow infections of sheep and goats. These viruses persist and can be isolated from blood and cerebrospinal fluid for years despite neutralizing antibody. In the studies reported here we have used quantitative in situ hybridization to analyze infected leukocytes. We show that (1) monocytes harbor the visna genome; and (2) virus gene expression is as constrained in this cell as it is in glial and epithelial cells. These results are in accord with a Trojan Horse mechanism of virus dissemination in an immunologically responsive host.