Strategies to reduce transmission of Toxoplasma gondii to animals and humans
Strategies to reduce transmission of Toxoplasma gondii to animals and humans
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DOI：
10.1016/0304-4017(96)00961-2
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发表时间：
1996-08-01
影响因子：
2.6
通讯作者：
Dubey, JP
中科院分区：
文献类型：
--
作者：
Dubey, JP
弓形虫存在于食用动物的组织中，是全世界绵羊和山羊流产和死亡的重要原因。它会导致先天感染儿童智力低下和视力丧失，并导致免疫抑制患者死亡。新西兰、英国和欧洲有一种使用非持久性弓形虫菌株的活疫苗，可防止绵羊弓形虫流产。美国正在开发一种使用弓形虫突变株（T-263）的活疫苗，以减少猫的卵囊脱落。迄今为止，还没有药物可以杀死人体或动物组织中的弓形虫组织包囊。冷冻至-12摄氏度、烹饪至67摄氏度的内部温度或伽马射线（0.5 kGy）可以杀死肉中的组织囊肿。
Toxoplasma gondii is found in the tissues of food animals and is an important cause of abortion and mortality in sheep and goats throughout the world. It causes mental retardation and loss of vision in congenitally infected children and death in immunosuppressed patients. A live vaccine, using a nonpersistent strain of T. gondii, is available in New Zealand, the UK and Europe which prevents T. gondii abortion in sheep. A live vaccine using a mutant strain of T. gondii (T-263) is being developed in the USA to reduce oocyst shedding by cats. As yet, there are no drugs to kill T. gondii tissue cysts in human or animal tissues. Freezing to -12 degrees C, cooking to an internal temperature of 67 degrees C, or gamma irradiation (0.5 kGy) can kill tissue cysts in meat.