Effect of fibroblast-derived differentiation inducing factor on the differentiation of human monocytoid and myeloid leukemia cell lines.
Effect of fibroblast-derived differentiation inducing factor on the differentiation of human monocytoid and myeloid leukemia cell lines.
复制标题
成纤维细胞源性分化诱导因子对人单核细胞和髓系白血病细胞系分化的影响。
DOI：
10.1016/s0006-291x(88)81044-1
复制
发表时间：
1988
影响因子：
3.1
通讯作者：
K. Konno
中科院分区：
文献类型：
--
作者：
K. Takeda;T. Hosoi;M. Noda;H. Arimura;K. Konno
从人成纤维细胞系（WI-26 VA 4）的条件培养基中纯化的成纤维细胞衍生的分化诱导因子（F-DIF）诱导人单核细胞白血病细胞系（U-937，THP-1）分化为具有巨噬细胞特征的细胞。F-DIF单独诱导的ML-1细胞的分化只有轻微的，但它协同增加分化时，与TNF。IFN-γ、TNF-α、GM-CSF、IL-1和IL-4与F-DIF联合应用可协同促进U-937细胞的分化。
A fibroblast-derived differentiation inducing factor (F-DIF) purified from medium conditioned by a human fibroblast cell line (WI-26VA4) induced differentiation of human monocytic leukemia cell lines (U-937, THP-1) into cells with macrophage characteristics. F-DIF alone induced the differentiation of ML-1 cells only marginally, but it synergistically increased the differentiation when combined with TNF. Interferon-γ, tumor necrosis factor, GM-CSF, interleukin-1 and interlukin-4 synergistically enhanced the differentiation of U-937 cells when combined with F-DIF.
影响因子：
56.9
作者：
SOUZA, LM;BOONE, TC;WELTE, K
通讯作者：
WELTE, K