7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients With Glioma
7-Tesla Susceptibility-Weighted Imaging to Assess the Effects of Radiotherapy on Normal-Appearing Brain in Patients With Glioma
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DOI：
10.1016/j.ijrobp.2011.05.046
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发表时间：
2012-03-01
影响因子：
7
通讯作者：
Nelson, Sarah J.
中科院分区：
文献类型：
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作者：
Lupo, Janine M.;Chuang, Cynthia F.;Nelson, Sarah J.
目的：利用7T磁化率加权成像（SWI）评估放射治疗对神经胶质瘤患者正常脑组织的中长期影像学表现。方法和材料：在7特斯拉磁体上对25例稳定神经胶质瘤患者进行SWI。微出血被确定为与血管不对应的离散易感灶。对 T2 高信号病变内部和外部的微出血数量进行计数。对于 3 名患者，重建辐射剂量图并与 7T SWI 数据融合。结果：放化疗 2 年后，在患者中观察到与微出血一致的多个易感病灶。未接受辐射的患者中不存在这些病变。微出血的发生率随着放疗完成后的时间而增加，并且这些病变常常延伸到初始高剂量体积的边界之外并进入对侧半球。 结论：高场 SWI 有潜力可视化与放疗对脑组织的长期影响相关的微出血的出现。在正常表现的脑组织中可视化这些病变的能力可能对于进一步了解这种治疗在生存期较长的患者中的效用很重要。 (C) 2012 爱思唯尔公司。
Purpose: To evaluate the intermediate- and long-term imaging manifestations of radiotherapy on normal-appearing brain tissue in patients with treated gliomas using 7T susceptibility-weighted imaging (SWI).Methods and Materials: SWI was performed on 25 patients with stable gliomas on a 7 Tesla magnet. Microbleeds were identified as discrete foci of susceptibility that did not correspond to vessels. The number of microbleeds was counted within and outside of the T2-hyperintense lesion. For 3 patients, radiation dosimetry maps were reconstructed and fused with the 7T SWI data.Results: Multiple foci of susceptibility consistent with microhemorrhages were observed in patients 2 years after chemoradiation. These lesions were not present in patients who were not irradiated. The prevalence of microhemorrhages increased with the time since completion of radiotherapy, and these lesions often extended outside the boundaries of the initial high-dose volume and into the contralateral hemisphere.Conclusions: High-field SWI has potential for visualizing the appearance of microbleeds associated with long-term effects of radiotherapy on brain tissue. The ability to visualize these lesions in normal-appearing brain tissue may be important in further understanding the utility of this treatment in patients with longer survival. (C) 2012 Elsevier Inc.