Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis
Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis
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DOI：
10.1136/gut.43.4.575
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发表时间：
1998-10-01
期刊：
影响因子：
24.5
通讯作者：
Kohno, S
中科院分区：
文献类型：
--
作者：
Ohba, K;Omagari, K;Kohno, S
肝细胞癌的自然消退是一种罕见的现象。由于一个组织的辐照对远端未辐照组织的影响而引起的肿瘤的抽象性消退也很少见。本文报告一位76岁日本男性肝癌患者，因胸部椎体骨转移而接受放射治疗后复发。放疗后血清肿瘤坏死因子- α水平升高。研究结果表明，这种体外相关的退化可能与宿主免疫反应有关，涉及肿瘤坏死因子- α等细胞因子。
Spontaneous regression of hepatocellular carcinoma is a rare phenomenon. Abscopal regression of tumours resulting from the effect of irradiation of a tissue on a remote non-irradiated tissue is also rare. The case of a 76 year old Japanese man with hepatocellular carcinoma that regressed after radiotherapy for thoracic vertebral bone metastasis is described. Serum levels of tumour necrosis factor-alpha increased after radiotherapy.:The findings suggests that such abscopal related regression may be associated with host immune response, involving cytokines such as tumour necrosis factor-alpha.