Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study
Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study
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色氨酸摄入量与日本怀孕期间抑郁症状的患病率较低有关：九州冲绳母婴健康研究的基线数据
DOI：
10.1007/s00394-022-02969-x
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发表时间：
2022
影响因子：
5
通讯作者：
Arakawa Masashi
中科院分区：
文献类型：
--
作者：
Miyake Yoshihiro;Tanaka Keiko;Okubo Hitomi;Sasaki Satoshi;Arakawa Masashi
目的色氨酸是一种完全来源于饮食的必需氨基酸。虽然大部分色氨酸通过犬尿氨酸途径被降解为喹啉酸和犬尿酸等神经活性代谢物，但摄入的色氨酸有一小部分被代谢成神经递质5-羟色胺。目前在日本进行的一项横断面研究调查了孕期色氨酸摄入量与抑郁症状之间的关系。前一个月的饮食摄入量是使用自我管理的饮食历史问卷进行评估的。抑郁症状被定义为流行病学研究中心抑郁量表上的≥ 16分。对年龄、孕周、居住地、子女数、家庭结构、抑郁史、抑郁家族史、吸烟、家庭和工作场所二手烟暴露、就业、家庭收入、文化程度、体重指数、饱和脂肪酸、二十碳五烯酸加二十二碳六烯酸、钙、维生素D和异黄酮类的摄入量进行了调整。调整混杂因素后，色氨酸摄入量增加与妊娠期抑郁症状的患病率呈独立负相关：色氨酸摄入量第一、二、三、四分位数中调整后的妊娠期抑郁症状患病率(95%可信区间)分别为1(参考)、0.99(0.76−1.28)、0.94(0.71−1.25)和0.64(0.44−0.93)(pFor趋势 = 0.04)。
ObjectiveTryptophan is an essential amino acid wholly derived from diet. While the majority of tryptophan is degraded through the kynurenine pathway into neuroactive metabolites like quinolinic acid and kynurenic acid, a small proportion of ingested tryptophan is metabolized into the neurotransmitter serotonin. The current cross-sectional study in Japan examined the association between tryptophan intake and depressive symptoms during pregnancy.MethodsStudy subjects were 1744 pregnant women. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. Depressive symptoms were defined as a score ≥ 16 on the Center for Epidemiologic Studies Depression Scale. Adjustment was made for age, gestation, region of residence, number of children, family structure, history of depression, family history of depression, smoking, secondhand smoke exposure at home and at work, employment, household income, education, body mass index, and intake of saturated fatty acids, eicosapentaenoic acid plus docosahexaenoic acid, calcium, vitamin D, and isoflavones.ResultsThe prevalence of depressive symptoms during pregnancy was 19.2%. After adjustment for confounding factors, higher tryptophan intake was independently inversely associated with the prevalence of depressive symptoms during pregnancy: the adjusted prevalence ratios (95% confidence intervals) for depressive symptoms during pregnancy in the first, second, third, and fourth quartiles of tryptophan intake were 1 (reference), 0.99 (0.76−1.28), 0.94 (0.71−1.25), and 0.64 (0.44−0.93), respectively (pfor trend = 0.04).ConclusionsHigher estimated tryptophan intake was cross-sectionally independently associated with a lower prevalence of depressive symptoms during pregnancy in Japanese women.