Different functional classes of genes are characterized by different compositional properties
Different functional classes of genes are characterized by different compositional properties
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DOI：
10.1016/j.febslet.2007.11.052
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发表时间：
2007-12-22
期刊：
影响因子：
3.5
通讯作者：
Saccone, Salvatore
中科院分区：
文献类型：
--
作者：
D'Onofrio, Giuseppe;Ghosh, Tapash Chandra;Saccone, Salvatore
对一组被归为几个功能类的人类基因进行了成分分析。我们发现，参与细胞代谢的基因的GC3，即第三密码子位置的GC水平显著高于参与信息存储和处理的基因。对人类/非洲爪哇同源基因的分析表明：(I)参与细胞代谢的基因的GC3增量显著高于参与信息存储和处理的基因；(Ii)在每个功能类别中，GC3与相应的GCI(即内含子的GC水平)之间存在很强的相关性。GC增量的非随机性有利于基因/基因组进化的选择性假说。(C)2007年欧洲生化学会联合会。爱思唯尔出版，版权所有。
A compositional analysis on a set of human genes classified in several functional classes was performed. We found out that the GC3, i.e. the GC level at the third codon positions, of the genes involved in cellular metabolism was significantly higher than those involved in information storage and processing. Analyses of human/Xenopus ortologous genes showed that: (i) the GC3 increment of the genes involved in cellular metabolism was significantly higher than those involved in information storage and processing; and (ii) a strong correlation between the GC3 and the corresponding GCi, i.e. the GC level of introns, was found in each functional class. The non-randomness of the GC increments favours the selective hypothesis of gene/genome evolution. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.