Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
Whole Genome Sequencing identifies reciprocal translocation hT2(I;III) breakpoints.
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DOI：
10.17912/micropub.biology.000505
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发表时间：
2021
影响因子：
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通讯作者：
Moerman DG
中科院分区：
文献类型：
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作者：
Flibotte S;Edgley M;Au V;Moerman DG
我们利用一株秀丽线虫HT2(I；III)双向易位纯合子的全基因组测序(WGS)数据，从分子水平上确定了HT2(I；III)的断裂点。易位结构相当简单，除了主要断点外，只有少量的二次重排。下面的图表描述了两个HT2半易位，以便于概念化。
We used whole-genome sequencing (WGS) data from a Caenorhabditis elegans strain homozygous for the reciprocal translocation hT2(I;III) to identify its breakpoints molecularly. The translocation structure is fairly straightforward, with only minor secondary rearrangement in addition to the primary breakpoints. The graphical representation below depicts the two hT2 half-translocations for ease of conceptualization.