Simian immunodeficiency virus infection and flow cytometric characterization of Japanese macaque ( Macaca fuscata ) hematopoietic cells
Simian immunodeficiency virus infection and flow cytometric characterization of Japanese macaque ( Macaca fuscata ) hematopoietic cells
复制标题
猿猴免疫缺陷病毒感染及日本猕猴（Macaca fuscata）造血细胞的流式细胞术表征
DOI：
10.1111/jmp.12460
复制
发表时间：
2020
影响因子：
0.7
通讯作者：
Okada Seiji
中科院分区：
文献类型：
--
作者：
Tsukamoto Tetsuo;Nakamura Katsuki;Okada Seiji
我们使用流式细胞术表征了日本猕猴（Macaca fuscata）造血细胞，并鉴定了28个交叉反应性抗人抗体克隆。此外，通过细胞内SIV p27染色证实了猴免疫缺陷病毒（SIV）在体外对外周血T淋巴细胞的生产性感染。本研究有助于将日本猕猴作为人类血液学和免疫学疾病及感染性疾病的模型。
We characterized Japanese macaque (Macaca fuscata) hematopoietic cells using flow cytometry and identified 28 cross‐reactive anti‐human antibody clones. Furthermore, productive infection of peripheral T lymphocytes with simian immunodeficiency virus (SIV) in vitro was confirmed by intracellular SIV p27 staining. This study could facilitate using Japanese macaques as models for human hematological and immunological disorders and infectious diseases.