Effect of cell culture conditions on the anticytomegalovirus activity of maribavir
Effect of cell culture conditions on the anticytomegalovirus activity of maribavir
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DOI：
10.1128/aac.00207-06
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发表时间：
2006-07-01
影响因子：
4.9
通讯作者：
Marousek, GI
中科院分区：
文献类型：
--
作者：
Chou, SW;Van Wechel, LC;Marousek, GI
巨细胞病毒UL97激酶抑制剂maribavir在肺成纤维细胞中比在皮肤成纤维细胞中更有效地抑制病毒的生长，一些细胞激酶抑制剂增强了其抗病毒活性。这些效应影响了药物敏感性的表型分析，并暗示了治疗上有用的maribavir和细胞激酶抑制剂组合的可能性。
The cytomegalovirus UL97 kinase inhibitor maribavir suppressed viral growth more effectively in lung fibroblasts than in skin fibroblasts, and some cellular kinase inhibitors enhanced its antiviral activity. These effects influence the phenotypic assay of drug susceptibility and suggest the possibility of therapeutically useful combinations of maribavir and cellular kinase inhibitors.