Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines
Proximal colon cancer in patients aged 51-60 years of age should be tested for microsatellites instability. A comment on the Revised Bethesda Guidelines
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DOI：
10.1007/s00384-008-0484-2
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发表时间：
2008-08-01
影响因子：
2.8
通讯作者：
Nitti, D.
中科院分区：
文献类型：
--
作者：
Urso, E.;Pucciarelli, S.;Nitti, D.
目的Bethesda指南建议在早发性直肠癌中进行微卫星不稳定性（MSI）检测，而在> 50岁的近端结肠癌患者中不进行MSI检测。本研究的目的是评估是否高MSI（MSI-H）的风险是更大的近端结肠癌的患者51-60岁比早发性直肠cancer.Methods连续性结直肠癌（CRC）患者进行了评估。记录肿瘤位置、癌症家族史、MSI状态和组织学。在MSI-H肿瘤中研究MLH 1/MSH 2中的突变。将患者再分为两组：A组，51-60岁的近端结肠癌患者; B、C和D组，
Purpose The Bethesda guidelines suggest to perform microsatellite instability (MSI) test in early onset rectal cancer and not in patients > 50 years with proximal colon cancer. The aim of the study was to evaluate whether the risk of high MSI (MSI-H) is greater in proximal colon cancer of patients 51-60 years old than in early-onset rectal cancer.Methods Consecutive colorectal cancer (CRC) patients were evaluated. Tumor location, cancer family history, MSI status and histology were recorded. Mutations in MLH1/MSH2 were investigated in MSI-H tumors. Patients were subdivided into groups: group A, proximal colon cancer patients 51-60 years old and groups B, C and D, patients