Tissue reactions of subcutaneously implanted mixture of ε-caprolactone-lactide copolymer and tricalcium phosphate.: An electron microscopic evaluation in sheep
Tissue reactions of subcutaneously implanted mixture of ε-caprolactone-lactide copolymer and tricalcium phosphate.: An electron microscopic evaluation in sheep
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DOI：
10.1023/a:1025642912270
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发表时间：
2003-10-01
影响因子：
3.7
通讯作者：
Suuronen, R
中科院分区：
文献类型：
--
作者：
Ekholm, M;Hietanen, J;Suuronen, R
生物可降解聚合物，主要是α-羟基酸的衍生物，目前广泛用于口腔颌面外科、整形外科和其他外科领域。这些生物材料被活组织良好地耐受，并且由聚乳酸或聚乙醇酸制成的骨折固定装置如今在临床上被广泛使用。但生物可降解聚合物的应用还存在一些问题。在临床引入这些器械后，已注意到非细菌性炎症反应。还报告了植入部位的肿胀和疼痛。尽管进行了大量研究，但这种炎症反应的病因仍然未知。因此，本研究的目的是通过电子显微镜进一步详细描述这种炎症反应。我们制备了ε-己内酯-丙交酯共聚物和磷酸三钙的混合物，并将其置于12只绵羊的真皮中。随访时间为9、14、24和52周。我们发现这种混合物引起了轻微的炎症反应。没有细胞损伤的迹象。在共聚物附近发现成纤维细胞、巨噬细胞和嗜酸性粒细胞。这种混合物很容易处理，可以在室温下模塑成不同的形状。这些结果鼓励我们继续研究，以开发骨缺损的填充材料。(C)2003 Kluwer Academic Publishers.
Biodegradable polymers, mainly derivates of alpha-hydroxy acids, are widely used today in oral- and maxillofacial surgery, orthopedics, and other fields of surgery. These biomaterials are well tolerated by living tissue and fracture fixation devices made of polylactic or polyglycolic acid are clinically widely used today. Still, there are some problems in application of biodegradable polymers. Abacterial inflammatory reactions have been noticed after the clinical introduction of these devices. Both swelling and pain at the site of implantation have also been reported. The etiology of this inflammatory reaction is still unknown, despite the numerous studies. Therefore, the aim of the present study was to further characterize this inflammatory reaction in detail, by electronmicroscopy. We prepared a mixture of epsilon-caprolactone-lactide copolymer and tricalcium phosphate and placed it in the dermis in 12 sheep. Follow-up times were 9, 14, 24, and 52 weeks. We found that the mixture caused a mild inflammatory reaction. There were no signs of cell damage. Fibroblasts, macrophages, and eosinophils were found adjacent to the copolymer. The mixture is easy to handle and can be moulded into different shapes in room temperature. The results encourage us to continue our studies to develop a filling material for bone defects. (C) 2003 Kluwer Academic Publishers.