Integrated co-regulation of bacterial arsenic and phosphorus metabolisms
Integrated co-regulation of bacterial arsenic and phosphorus metabolisms
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DOI：
10.1111/j.1462-2920.2012.02881.x
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发表时间：
2012-12-01
影响因子：
5.1
通讯作者：
McDermott, Timothy R.
中科院分区：
文献类型：
--
作者：
Kang, Yoon-Suk;Heinemann, Joshua;McDermott, Timothy R.
砷在美国环境保护署超级基金有害物质清单中排名第一。其流动性和毒性取决于化学形态，这是显着驱动微生物氧化还原转化。基因组序列使调查显示，在许多微生物中，亚砷酸盐（AsIII）氧化所必需的基因位于紧邻的基因编码与磷（Pi）收购相关的功能，这意味着某种类型的功能的重要性，作为，Pi或两者的代谢。我们广泛地记录了AsIII氧化和Pi胁迫反应的关键基因的表达如何在土壤细菌根癌农杆菌中复杂地共同调节。这些观察结果显着扩大了我们的理解，环境因素如何影响微生物的As III代谢，并有助于目前的讨论中的微生物细胞中的As和P代谢。
Arsenic ranks first on the US Environmental Protection Agency Superfund List of Hazardous Substances. Its mobility and toxicity depend upon chemical speciation, which is significantly driven by microbial redox transformations. Genome sequence-enabled surveys reveal that in many microorganisms genes essential to arsenite (AsIII) oxidation are located immediately adjacent to genes coding for functions associated with phosphorus (Pi) acquisition, implying some type of functional importance to the metabolism of As, Pi or both. We extensively document how expression of genes key to AsIII oxidation and the Pi stress response are intricately co-regulated in the soil bacterium Agrobacterium tumefaciens. These observations significantly expand our understanding of how environmental factors influence microbial AsIII metabolism and contribute to the current discussion of As and P metabolism in the microbial cell.