EMERGENCE OF ALPHA-5-BETA-1 FIBRONECTIN-RECEPTOR AND ALPHA-V-BETA-3 VITRONECTIN-RECEPTOR EXPRESSION IN MELANOCYTIC TUMOR PROGRESSION
EMERGENCE OF ALPHA-5-BETA-1 FIBRONECTIN-RECEPTOR AND ALPHA-V-BETA-3 VITRONECTIN-RECEPTOR EXPRESSION IN MELANOCYTIC TUMOR PROGRESSION
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DOI：
10.1111/j.1365-2559.1994.tb00517.x
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发表时间：
1994-03-01
期刊：
影响因子：
6.4
通讯作者：
RUITER, DJ
中科院分区：
文献类型：
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作者：
DANEN, EHJ;TENBERGE, PJM;RUITER, DJ
细胞粘附在肿瘤进展过程中至关重要。由于整联蛋白是参与细胞粘附的重要受体分子，我们研究了α 1-6、α v、α IIb、β 1、β 3和β 4整联蛋白亚基在常见痣细胞痣（n=22）、发育不良痣（16）、薄（24）和厚原发性皮肤黑色素瘤（28）和黑色素瘤转移瘤（25）组织切片中的分布。我们发现了α 1/α 2、α 4/α 5/β 3和α 6/β 4的相关表达。发现α 6和β 4的减少以及α 4和α v的增加与黑色素瘤进展相关。此外，α 5和β 3的表达仅在原发性黑色素瘤和转移性黑色素瘤中检测到。我们的研究结果表明，在黑色素瘤进展过程中，整合素表达发生变化，最引人注目的是α 5 β 1纤连蛋白和α v β 3 Vitonectin受体的出现。
Cell adhesion is crucial in the process of tumour progression. As integrins are important receptor molecules involved in cell adhesion, we studied the distribution of the alpha 1-6, alpha v, alpha IIb, beta 1, beta 3, and beta 4 integrin subunits in tissue sections of common naevocellular naevi (n=22), dysplastic naevi (16), thin (24) and thick primary cutaneous melanomas (28), and melanoma metastases (25). We found correlated expression of alpha 1/alpha 2, of alpha 4/alpha 5/beta 3, and of alpha 6/beta 4. Decrease of alpha 6 and beta 4, and increase of alpha 4 and alpha v were found to be correlated with melanoma progression. Furthermore, expression of alpha 5 and beta 3 was detected only in primary melanoma and melanoma metastasis. Our findings indicate that during melanoma progression alterations in integrin expression occur, the most striking being emergence of alpha 5 beta 1 fibronectin and alpha v beta 3 vitonectin receptor.