Outcome Following Thiopurine Use in Children With Ulcerative Colitis: A Prospective Multicenter Registry Study
Outcome Following Thiopurine Use in Children With Ulcerative Colitis: A Prospective Multicenter Registry Study
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DOI：
10.1038/ajg.2010.493
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发表时间：
2011-05-01
影响因子：
9.8
通讯作者：
Markowitz, James
中科院分区：
文献类型：
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作者：
Hyams, Jeffrey S.;Lerer, Trudy;Markowitz, James
OBJECTIVES: Despite little supporting data, thiopurine use is common in pediatric ulcerative colitis (UC). Our aim was to determine outcome following thiopurine use in a multicenter inception cohort of children diagnosed with UC.METHODS: Data were obtained from a prospective observational study of newly diagnosed children < 16 years of age. Data are recorded at diagnosis, 30 days, and quarterly. Patients are managed by physician dictates not protocol. Disease activity is classified by physician global assessment. The primary outcome was corticosteroid (CS)-free inactive UC at 1 year following thiopurine initiation without the need for rescue therapy (infliximab, calcineurin inhibitors, or colectomy).RESULTS: Of 1,490 patients in our registry, 394 have UC (mean age at diagnosis 11.3 +/- 3.7 years); 197 (50%) received thiopurine (49%
