World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation.
World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation.
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DOI：
10.1007/s12035-022-03059-z
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发表时间：
2023-01
影响因子：
5.1
通讯作者：
Luft, Benjamin J.
中科院分区：
文献类型：
--
作者：
Huang, Chuan;Kritikos, Minos;Sosa, Mario Serrano;Hagan, Thomas;Domkan, Alan;Meliker, Jaymie;Pellecchia, Alison C.;Santiago-Michels, Stephanie;Carr, Melissa A.;Kotov, Roman;Horton, Megan;Gandy, Sam;Sano, Mary;Bromet, Evelyn J.;Lucchini, Roberto G.;Clouston, Sean A. P.;Luft, Benjamin J.
关键词：
2001年9月11日世界贸易中心（WTC）袭击事件的响应者吸入了有毒粉尘，并经历了长时间的严重创伤。研究报告称，WTC部位暴露时间与外周炎症和早发性痴呆（EOD）风险相关。游离水分数（FWF）可以通过测量游离水在神经元中的体内运动而用作神经炎症的生物标志物。本病例对照研究旨在研究WTC部位暴露持续时间以及EOD状态与海马和脑神经炎症增加之间的相关性。2017年至2019年间招募了99名WTC响应者（平均年龄为56岁）（N = 48名EOD患者和51名认知未受损的患者）。参与者在年龄，性别，职业，种族，教育和创伤后应激障碍（PTSD）状态方面相匹配。参与者接受了使用扩散张量成像协议进行FWF提取的神经成像。感兴趣区（ROI）分析和相关纤维束成像探讨地形分布的FWF协会。大多数应答者（N = 91）的载脂蛋白-e4等位基因（APOEε4）状态可用。海马FWF与WTC部位暴露持续时间显著相关（r = 0.30，p = 0.003），大脑白色物质FWF也是如此（r = 0.20，p = 0.044）。ROI分析和相关纤维束成像确定了边缘、额叶和颞叶内的区域。当存在APOEε4等位基因时，海马FWF及其与WTC暴露持续时间的相关性最高（r = 0.48，p = 0.039）。我们的研究结果表明，WTC部位长期暴露与WTC应答者海马和大脑白色神经炎症增加相关，可能因APOEε4等位基因的存在而加剧。
Responders to the World Trade Center (WTC) attacks on 9/11/2001 inhaled toxic dust and experienced severe trauma for a prolonged period. Studies report that WTC site exposure duration is associated with peripheral inflammation and risk for developing early-onset dementia (EOD). Free Water Fraction (FWF) can serve as a biomarker for neuroinflammation by measuring in vivo movement of free water across neurons. The present case-controlled study aimed to examine associations between WTC site exposure duration as well as EOD status with increased hippocampal and cerebral neuroinflammation. Ninety-nine WTC responders (mean age of 56) were recruited between 2017 and 2019 (N = 48 with EOD and 51 cognitively unimpaired). Participants were matched on age, sex, occupation, race, education, and post-traumatic stress disorder (PTSD) status. Participants underwent neuroimaging using diffusion tensor imaging protocols for FWF extraction. Region of interest (ROI) analysis and correlational tractography explored topographical distributions of FWF associations. Apolipoprotein-e4 allele (APOEε4) status was available for most responders (N = 91). Hippocampal FWF was significantly associated with WTC site exposure duration (r = 0.30, p = 0.003), as was cerebral white matter FWF (r = 0.20, p = 0.044). ROI analysis and correlational tractography identified regions within the limbic, frontal, and temporal lobes. Hippocampal FWF and its association with WTC exposure duration were highest when the APOEε4 allele was present (r = 0.48, p = 0.039). Our findings demonstrate that prolonged WTC site exposure is associated with increased hippocampal and cerebral white matter neuroinflammation in WTC responders, possibly exacerbated by possession of the APOEε4 allele.
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影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
14
作者：
通讯作者：
--
影响因子：
2.1
作者：
Freitas, Sandra;Simoes, Mario Rodrigues;Santana, Isabel
通讯作者：
Santana, Isabel
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
7.7
作者：
Dasaro, Christopher R.;Holden, William L.;Todd, Andrew C.
通讯作者：
Todd, Andrew C.