Impaired β cell function in Chinese newly diagnosed type 2 diabetes mellitus with hyperlipidemia.
Impaired β cell function in Chinese newly diagnosed type 2 diabetes mellitus with hyperlipidemia.
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DOI：
10.1155/2014/493039
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发表时间：
2014
影响因子：
4.3
通讯作者：
Peng Y
中科院分区：
文献类型：
--
作者：
Ma Y;Wang Y;Huang Q;Ren Q;Chen S;Zhang A;Zhao L;Zhen Q;Peng Y
目的是探讨高脂血症对新诊断2型糖尿病（T2DM）患者β细胞功能的影响。208例患者入组研究，分为新诊断T2DM合并高脂血症（132例）和无高脂血症（76例）。比较两组患者的人口学数据、血糖水平、胰岛素水平、血脂、β细胞功能指数稳态模型评估（HOMA-β）、胰岛素抵抗指数稳态模型评估（HOMA- ir）和胰岛素敏感性定量检查指数（QUICKI）。我们发现，与正常血脂水平的受试者相比，新诊断T2DM合并高脂血症的受试者更年轻，HOMA-β下降。然而，无论不同的脂质谱（合并高脂血症、高甘油三酯血症和高胆固醇血症），HOMA-β水平具有可比性。多元逐步线性回归分析显示，空腹血糖升高（FPG）、空腹胰岛素水平降低（FINS）和高甘油三酯（TG）是新诊断T2DM患者β细胞功能障碍的独立危险因素。因此，血脂异常的管理和血糖控制可能对伴有高脂血症的2型糖尿病有益。
The objective is to explore the effects of hyperlipidemia on β cell function in newly diagnosed type 2 diabetes mellitus (T2DM). 208 patients were enrolled in the study and were divided into newly diagnosed T2DM with hyperlipidemia (132 patients) and without hyperlipidemia (76 patients). Demographic data, glucose levels, insulin levels, lipid profiles, homeostasis model assessment for β cell function index (HOMA-β), homeostasis model assessment for insulin resistance index (HOMA-IR), and quantitative insulin-sensitivity check index (QUICKI) were compared between the two groups. We found that comparing with those of normal lipid levels, the subjects of newly diagnosed T2DM with hyperlipidemia were younger, and had declined HOMA-β. However, the levels of HOMA-β were comparable regardless of different lipid profiles (combined hyperlipidemia, hypertriglyceridemia, and hypercholesterolemia). Multiple stepwise linear regression analysis showed that high fasting plasma glucose (FPG), decreased fasting insulin level (FINS), and high triglyceride (TG) were independent risk factors of β cell dysfunction in newly diagnosed T2DM. Therefore, the management of dyslipidemia, together with glucose control, may be beneficial for T2DM with hyperlipidemia.