ChromatinDB:: a database of genome-wide histone modification patterns for Saccharomyces cerevisiae
ChromatinDB:: a database of genome-wide histone modification patterns for Saccharomyces cerevisiae
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DOI：
10.1093/bioinformatics/btm236
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发表时间：
2007-07-15
期刊：
影响因子：
5.8
通讯作者：
Wyrick, John J.
中科院分区：
文献类型：
--
作者：
O'Connor, Timothy R.;Wyrick, John J.
组蛋白的共价修饰在调节基因转录中发挥着关键作用。先前的研究使用基于染色质免疫沉淀 (ChIP) 的微阵列分析来分析特定组蛋白修饰富集或缺失的基因组区域。此类研究已在酿酒酵母中广泛进行，但目前没有可用于这些数据集的综合数据存储库或分析工具。为此，我们开发了 ChromatinDB 数据库，其中包含酿酒酵母中 22 种不同组蛋白或组蛋白修饰的全基因组 ChIP 数据。 ChromatinDB 提供了新颖的工具来促进用户选择的基因集的染色质特征的可视化和统计分析。
Covalent modifications to histone proteins play a critical role in regulating gene transcription. Previous studies have used chromatin immunoprecipitation (ChIP) based microarray assays to profile genomic regions that are enriched or depleted for a particular histone modification. Such studies have been conducted extensively in the yeast Saccharomyces cerevisiae, but currently no comprehensive data repositories or analysis tools are available for these data sets. For this reason, we have developed the ChromatinDB database, which contains genome-wide ChIP data for 22 different histones or histone modifications in S.cerevisiae. ChromatinDB provides novel tools to facilitate the visualization and statistical analysis of chromatin features for user-selected gene sets.