Decreased Prevalence of Lymphatic Filariasis Among Subjects with Type-1 Diabetes
Decreased Prevalence of Lymphatic Filariasis Among Subjects with Type-1 Diabetes
复制标题
DOI：
10.4269/ajtmh.2010.10-0410
复制
发表时间：
2010-12-01
影响因子：
3.3
通讯作者：
Babu, Subash
中科院分区：
文献类型：
--
作者：
Aravindhan, Vivekanandhan;Mohan, Vishwanathan;Babu, Subash
一些动物研究表明，蠕虫感染对1型糖尿病(T1 DM)有保护作用。然而，尽管淋巴丝虫病(LF)的患病率与过敏和自身免疫的患病率呈负相关，但流行病学研究证明这种与T1 DM的保护性关系在很大程度上是缺乏的。在印度南部进行了一项横断面研究，以评估T1 DM患者(n=200)和正常糖耐量(NGT)患者(n=562)LF血清阳性的基线患病率。T1 DM组LF患病率为0%，NGT组为2.6%(P=0.026)。T1 DM患者丝虫抗原特异性Ig G4(但非抗原特异性Ig G)阳性的百分率(2%)也显著低于NGT患者(28%)(P<；0.001)。因此，在印度南部，低频和T1糖尿病的患病率之间似乎存在显著的相反关系。
Several animal studies have shown a protective effect of helminth infections against type-1 diabetes mellitus (T1DM). However, epidemiologic studies demonstrating this protective relationship with T1DM are largely lacking, although an inverse correlation between the prevalence of lymphatic filariasis (LF) and prevalence of allergies and autoimmunity has been shown. A cross-sectional study was undertaken in southern India to assess the baseline prevalence of seropositivity of LF among persons with T1DM (n = 200) and normal glucose tolerant (NGT) persons (n = 562). The prevalence of LF was 0% among persons with T1DM and 2.6% among NGT persons (P = 0.026). The percentage of persons who were positive for filarial antigen-specific IgG4 (but not antigen-specific IgG) was also significantly lower in persons with T1DM (2%) compared with NGT persons (28%) (P < 0.001). Thus, there appears to be a striking inverse relationship between the prevalence of LF and T1DM in southern India.