Isobutyl Nitrite-Mediated Synthesis of Quinoxalines through Double C-H Bond Amination of N-Aryl Enamines
Isobutyl Nitrite-Mediated Synthesis of Quinoxalines through Double C-H Bond Amination of N-Aryl Enamines
复制标题
亚硝酸异丁酯介导的 N-芳基烯胺双 C-H 键胺化合成喹喔啉
DOI：
10.1002/adsc.201800928
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发表时间：
2018
影响因子：
5.4
通讯作者：
Su Gui-Fa
中科院分区：
文献类型：
--
作者：
Jiao Yan-Xiao;Wei Lin-Su;Zhao Chun-Yang;Wei Kai;Mo Dong-Liang;Pan Cheng-Xue;Su Gui-Fa
An efficient and metal‐free double C−H bond amination ofN‐aryl enamines using isobutyl nitrite (IBN) has been developed. This method enables the preparation of functionalized quinoxalines in good to excellent yields and tolerates a variety ofN‐aryl enamines with diverse functional substituents. Mechanistic studies revealed the presence of a keyβ‐imino oxime ester intermediate. A quinoxaline derivative could be prepared fromβ‐carbonyl ester in one‐pot sequence on a gram scale. Finally, two important quinoxaline scaffolds were easily prepared in moderate yields over two steps.
