Effect of induced metabolic alkalosis on sweat composition in men
Effect of induced metabolic alkalosis on sweat composition in men
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DOI：
10.1046/j.1365-201x.2002.00927.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Nimmo, MA
中科院分区：
文献类型：
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作者：
Patterson, MJ;Galloway, SDR;Nimmo, MA
为了确定诱导的代谢性出汗是否影响汗液成分，10只雄性在两个不同的场合以62.5 +/- 1.3%峰值摄氧量循环90分钟。受试者在2小时内摄入空胶囊（安慰剂）或含NaHCO 3-（0.3 g kg（-1）体重; 6个相等剂量）的胶囊，从运动前3小时开始。在运动前和运动后15、30、60和90分钟抽取动脉-静脉血样。运动结束时从右侧肩胛骨区域的贴片上吸出汗液，NaHCO 3摄入使安静和运动时的血液pH、[HCO 3-]和血清[Na+]升高，而血清[Cl-]和[K+]降低（P < 0.05）。在NaHCO 3试验中，汗液pH值更高（6.24 +/- 0.18 vs. 6.38 +/- 0.18; P < 0.05），而汗液[Na+]（49.5 +/- 4.8与50.2 +/- 4.3 mEq L-1），[Cl-]（37.5 +/- 5.1 vs 39.3 +/- 4.2 mEq L-1）和[K+]（4.66 +/- 0.19 vs，4.64 +/- 0.34 mEq L-1）在试验之间没有差异（P > 0.05）。汗水（HCO 3-]（2.49 +/- 0.58 vs. 3.73 +/- 1.10 mEq L-1）和[乳酸盐]摄入NaHCO 3后（8.92 +/- 0.79 vs 10.51 +/- 0.32 mmol L-1）往往更大，但未达到显著性这些数据表明，诱导的代谢性出汗可以改变汗液成分，尽管目前还不清楚分泌线圈、重吸收管或两者是否负责这种改变。
To determine whether induced metabolic alkalosis affects sweat composition, 10 males cycled for 90 min at 62.5 +/- 1.3% peak oxygen uptake, on two separate occasions. Subjects ingested either empty capsules (placebo) or capsules containing NaHCO3- (0.3 g kg(-1) body mass; six equal doses) over a 2-h period, which commenced 3 h prior to exercise. Arterialized-venous blood samples were drawn prior to and after 15, 30, 60 and 90 min of exercise. Sweat was aspirated at the end of exercise from a patch located on the right scapula region, NaHCO3- ingestion elevated blood pH, [HCO3-] and serum [Na+], whereas serum [Cl-] and [K+] were reduced, both at rest and during exercise (P < 0.05). Sweat pH was greater in the NaHCO3- trial (6.24 +/- 0.18 vs. 6.38 +/- 0.18; P < 0.05), whereas sweat [Na+] (49.5 +/- 4.8 vs. 50.2 +/- 4.3 mEq L-1), [Cl-] (37.5 +/- 5.1 vs. 39.3 +/- 4.2 mEq L-1) and [K+] (4.66 +/- 0.19 vs, 4.64 +/- 0.34 mEq L-1) did not differ between trials (P > 0.05). Sweat (HCO3-] (2.49 +/- 0.58 vs. 3.73 +/- 1.10 mEq L-1) and [lactate] (8.92 +/- 0.79 vs. 10.51 +/- 0.32 mmol L-1) tended to be greater after NaHCO3- ingestion, although significance was not reached (P = 0.07 and P = 0.08, respectively), These data indicate that induced metabolic alkalosis can modify sweat composition, although it is unclear whether the secretory coil, reabsorptive duct, or both are responsible for this alteration.