Circadian expression of pineal 5-lipoxygenase mRNA.
Circadian expression of pineal 5-lipoxygenase mRNA.
复制标题
松果体 5-脂氧合酶 mRNA 的昼夜节律表达。
DOI：
10.1097/00001756-199803300-00003
复制
发表时间：
1998
期刊：
影响因子：
1.7
通讯作者：
Manev,H
中科院分区：
文献类型：
--
作者：
Uz,T;Manev,H
IN lymphocytes, the pineal hormone, melatonin, suppresses 5-lipoxygenase (5-LO) gene expression. Because circadian fluctuations in melatonin content are prominent in the pineal, we hypothesized that 5-LO mRNA level in this gland is greater when melatonin is low (day) than at night. Using the reverse transcription/polymerase chain reaction we assayed the levels of mRNAs coding for 5-LO, serotonin N-acetyltransferase (NAT), and for a constitutive gene, cyclophilin, in rat pineals obtained at 10: 30–11: 00 h (day) or 24: 30–01: 00 (night). Cyclophilin mRNA was not affected by circa-dian rhythm, whereas 5-LO and NAT were affected in an opposite manner: 5-LO mRNA was high during the day, NAT mRNA at night. We propose that circadian pineal 5-LO expression might play a role in circadian regulation of pineal functioning.
