The relationship between risk attitude and treatment choice in patients with relapsing-remitting multiple sclerosis
The relationship between risk attitude and treatment choice in patients with relapsing-remitting multiple sclerosis
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DOI：
10.1177/0272989x02238299
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发表时间：
2002-11-01
影响因子：
3.6
通讯作者：
Weinstein, MC
中科院分区：
文献类型：
--
作者：
Prosser, LA;Kuntz, KM;Weinstein, MC
背景许多适合β-干扰素或醋酸格拉替雷治疗的多发性硬化症（MS）患者选择放弃或停止治疗。本研究的目的是评估风险态度作为一个患者的特征与MS患者的治疗选择。62例MS患者完成了关于治疗史、风险偏好、社会经济和临床变量的调查。使用多项逻辑回归来评估治疗选择与风险态度之间的关系。风险态度是用一个标准的赌博问题的短期健康结果。结果与风险厌恶型患者相比，风险寻求型患者选择治疗的可能性更小（P < 0.01）。对于停止治疗的患者，具有显著性的解释变量是副作用的严重程度（P < 0.05）。结论.风险态度是与MS患者的治疗开始相关的患者特征。这可能是确定个体患者的最佳治疗决策时需要考虑的重要因素。
Background. Many patients with multiple sclerosis (MS) eligible for beta-interferons or glatiramer acetate have chosen to forgo or discontinue treatment. The objective of this study was to evaluate risk attitude as a patient characteristic related to treatment choice for patients with MS. Methods. Sixty-two MS patients completed a survey on treatment history, risk preference, and socioeconomic and clinical variables. Multinomial logistic regression was used to assess the relationship between treatment choice and risk attitude. Risk attitude was measured using a standard gamble question on short-term health outcomes. Results. More risk-seeking patients were less likely to choose treatment compared with more risk-averse patients (P < 0.01). For patients who discontinued treatment, the explanatory variable of significance was severity of side effects (P < 0.05). Conclusions. Risk attitude is a patient characteristic related to treatment initiation in patients with MS. This could be an important factor to consider when identifying optimal treatment decisions for individual patients.