EFFECTS OF UNILATERAL ENTORHINAL CORTEX LESION AND GANGLIOSIDE GM1 TREATMENT ON PERFORMANCE IN A NOVEL WATER MAZE TASK
EFFECTS OF UNILATERAL ENTORHINAL CORTEX LESION AND GANGLIOSIDE GM1 TREATMENT ON PERFORMANCE IN A NOVEL WATER MAZE TASK
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DOI：
10.1006/nlme.1995.0003
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发表时间：
1995-11-01
影响因子：
2.7
通讯作者：
STEIN, DG
中科院分区：
文献类型：
--
作者：
GLASIER, MM;SUTTON, RL;STEIN, DG
据报道，单侧内嗅皮质（EC）损伤后会出现短暂性功能障碍。为了确定是否有更持久的赤字，成年雄性Sprague-Dawley大鼠与电解质或假病变的左内嗅皮层进行了检查收购的修改工作记忆任务。在莫里斯水迷宫里这种延迟的匹配到样本的任务，与1小时的试验间隔，揭示了显着的赤字，在总距离平台的介绍（试验1）和匹配（试验2）的大鼠内嗅病变。我们还发现，该试验可用于评估内嗅病变大鼠持续性（重复非生产性运动）的显著缺陷。损伤后16天仍可见缺损。神经节苷脂GM 1的管理导致在两个水迷宫措施分析的性能中度改善。对所有组（假手术组、用生理盐水处理的损伤组和用神经节苷脂GM 1处理的损伤组）进行三项其他测试，这些测试用于评估可能导致水迷宫性能不足的因素。探索新物体的一次试验测试显示，任何组都没有明显的、简单的工作记忆缺陷。加上迷宫测试，以评估可能的差异，在焦虑水平或增加活动作为水迷宫性能的一个组成部分，也没有发现在三组之间的差异。通过监测活动水平，所有组的运动活动也相似。EC损伤后大鼠水迷宫表现的恶化可能与其工作记忆能力的下降有关。一个更复杂的空间学习任务。(C)出版社：Academic Press
Transient deficits have been reported after unilateral entorhinal cortex (EC) lesion. To determine whether there is a more persistent deficit, adult male Sprague-Dawley rats with electrolytic or sham lesions of the left entorhinal cortex were examined on acquisition of a modified working memory task. in the Morris water maze. This delayed matching-to-sample task, with a 1-h intertrial interval, reveals a significant deficit in total distance to platform in both presentation (Trial 1) and matching (Trial 2) in the rats with entorhinal lesions. We have also found that this test can be used to assess significant deficits in perseveration (repeated nonproductive movement) in rats with entorhinal lesions. The deficits can be seen up to 16 days postinjury. Administration of ganglioside GM1 resulted in a moderate improvement in performance in both water maze measures analyzed. All groups (sham operated, lesion with saline treatment, and lesion with ganglioside GM1 treatment) were given three other tests, which were used to evaluate possible contributing factors to deficient water maze performance. A one-trial test for exploration of novel objects revealed no significant, simple working memory deficit in any group. Plus maze testing, to assess possible differences in levels of anxiety or increased activity as a component of water maze performance, also revealed no differences in the three groups. All groups were also similar in motor activity, shown by monitoring of activity levels. The worsened water maze performance observed in rats with EC lesion may be related to deficits in working memory ability within the framework. of acquisition of a more complex spatial learning task. (C) 1995 Academic Press, Inc.