Cerebellar volume of musicians
Cerebellar volume of musicians
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DOI：
10.1093/cercor/13.9.943
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发表时间：
2003-09-01
期刊：
影响因子：
3.7
通讯作者：
Schlaug, G
中科院分区：
文献类型：
--
作者：
Hutchinson, S;Lee, LHL;Schlaug, G
有证据表明，小脑参与人类的运动学习和认知功能。动物实验发现，小脑的结构变化是对长期运动技能活动的反应。我们通过分析来自大型前瞻性数据库的高分辨率t -1加权MR图像（n = 120），研究了专业键盘手的小脑体积是否比非音乐家更大，这些键盘手在生命早期就学习了专门的运动技能，并在一生中进行了密集的练习。与非音乐家相比，男性音乐家的小脑体积绝对（P = 0.018）和相对（P = 0.006）显著增加，但总脑体积没有增加。男性音乐家组终生练习强度与相对小脑体积相关（r = 0.595, P = 0.001）。在女性组中，音乐家和非音乐家之间的音量测量没有显着差异。性别对小脑相对体积的显著主要影响（F = 10.41, P < 0.01），女性小脑相对体积更大，可能掩盖了女性组音乐能力的影响。我们认为，男性音乐家的小脑体积显著增大，以及相对小脑体积与终生练习强度之间的正相关，代表了人类小脑对长期运动和认知功能需求的结构适应。
There is evidence that the cerebellum is involved in motor learning and cognitive function in humans. Animal experiments have found structural changes in the cerebellum in response to long-term motor skill activity. We investigated whether professional keyboard players, who learn specialized motor skills early in life and practice them intensely throughout life, have larger cerebellar volumes than matched non-musicians by analyzing high-resolution T-1-weighted MR images from a large prospectively acquired database (n = 120). Significantly greater absolute (P = 0.018) and relative (P = 0.006) cerebellar volume but not total brain volume was found in male musicians compared to male non-musicians. Lifelong intensity of practice correlated with relative cerebellar volume in the male musician group (r = 0.595, P = 0.001). In the female group, there was no significant difference noted in volume measurements between musicians and non-musicians. The significant main effect for gender on relative cerebellar volume (F = 10.41, P < 0.01), with females having a larger relative cerebellar volume, may mask the effect of musicianship in the female group. We propose that the significantly greater cerebellar volume in male musicians and the positive correlation between relative cerebellar volume and lifelong intensity of practice represents structural adaptation to long-term motor and cognitive functional demands in the human cerebellum.